Social Isolation and Aging in Schizophrenia Study
This observational study is looking at how social isolation and aging affect people with schizophrenia and related disorders. Researchers want to understand why individuals with these conditions often experience health problems typically seen later in life, earlier than others. They will be looking at new health conditions that develop, your general health using a survey (SF-36), and if you have high cholesterol. You may be able to join if you are between 40 and 70 years old and have a diagnosis of schizophrenia, schizoaffective disorder, or a similar condition. The study is currently unclear on its recruitment status and plans to include about 650 participants.
- Study design
- This is an observational study, meaning researchers will be looking at existing health information and collecting new data. It combines past research data with new follow-up assessments.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- Researchers will measure newly diagnosed conditions, health survey results, and high cholesterol at Day 1 of your participation.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Social Isolation and Aging in Schizophrenia
At a glance
Conditions
Where it's being run
4 sites across 4 statesStudy leadership
- Abraham Reichenberg · PRINCIPAL_INVESTIGATOR · Icahn School of Medicine at Mount Sinai
Who to contact
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Do you actually qualify for this trial?
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Inclusion
What this trial measures
- Occurrence of newly diagnosed conditionsDay 1
Physician diagnosed medical conditions - Medical records from hospitals and general practitioners will be reviewed to identify the occurrence and timing of any newly diagnosed conditions (e.g., cardiovascular disease, COPD, diabetes).
- Short Form Health Survey (SF-36),Day 1
The 36-Item Short Form Health Survey (SF-36), which includes five physical domains: physical functioning, role limitations due to physical problems, bodily pain, general health, and vitality. The individuals item scores (scored between 1-60, according to the manual) are summed to scale scores and transformed to a 100-point scale, with higher scores indicating a better health status.
- Number of Participants with High CholesterolDay 1
High cholesterol (defined as low-density lipoprotein ≥160 mg/dL or total cholesterol ≥240 mg/dL)
- Number of participants with High Blood PressureDay 1
High blood pressure (defined as systolic ≥130 mm Hg or diastolic ≥80 mm Hg).
- Schedule for Deficit Syndrome (SDS)Chart Review for the legacy data from when participants were first assessed between 2004 and 2015
Social isolation is measured with the Schedule for Deficit Syndrome (SDS) - each item scored from 0 (normal) to 4 (severely impaired). there is also a global severity score (0 to 4). Full scale scored from 0 to 20, with higher score representing greater severity of symptoms.
- The Birchwood social functioning scale (SFS)Chart review for the legacy data from when participants were first assessed between 2004 and 2015; and Three times daily for 14 days
Social isolation is measured with the Birchwood social functioning scale (SFS) - a 79 item instrument, and consists of seven subscales: (1) social engagement/withdrawal (amount of time to spend alone, the likelihood to initiate conversation); (2) interpersonal behaviour (number of friends, engagement in a romantic relationship); (3) prosocial activities (participation in social activities e.g. visit friends, play sports); (4) recreation (engagement in activities and hobbies); (5) independence-competence (ability to maintain independent living); (6) independence-performance (performance of the skills required for independent living); (7) employment/occupation (engagement in employment), The sum of each scale, and the full scale is standardized and normalized with a mean of 100 and standard deviation of 15. Higher scores represent better health outcomes.
- 'Social Isolation' subscale of the Structured Interview for Schizotypy-Revised (SIS-R)Chart review for the legacy data from when participants were first assessed between 2004 and 2015; and Three times daily for 14 days
Social isolation is measured with the 'Social Isolation' subscale of the Structured Interview for Schizotypy-Revised (SIS-R). The subscale range from 0 (virtually no evidence of symptoms) to 6 (symptoms present and quite severe).