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A Study of Auricular Transcutaneous Vagus Nerve Stimulation for Chronic Dizziness

This study is looking into a treatment called auricular transcutaneous vagus nerve stimulation (aTVNS) for people with chronic dizziness, specifically Persistent Postural-Perceptual Dizziness (PPPD). aTVNS involves using a device to deliver gentle electrical stimulation to a nerve in your outer ear. Researchers want to see if this treatment can reduce your dizziness over a 4-week period, measured by changes in your Dizziness Handicap Inventory (DHI) score. You might be able to join if you are 18-75 years old, have had persistent dizziness for at least 3 months, and experience at least one dizziness flare-up per day. The study is currently recruiting 60 participants, but its overall status is unclear.

Study design
This study is interventional, meaning participants will receive a specific treatment. It involves 60 participants and compares aTVNS to a sham device that mimics stimulation without delivering electricity.
What's involved
You would participate in a 4-week treatment period. Your dizziness will be measured at the beginning and end of this period.
Compensation
Not stated in the trial record.
Follow-up
Your dizziness will be measured at baseline and after 4 weeks of treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07420803

A Study Of Auricular Transcutaneous Vagus Nerve Stimulation In Chronic Dizziness

Recruiting
NAAges 18+InterventionalTreatment
Mayo Clinic
~60 participants
Updated 2026-04-17 on ClinicalTrials.gov
What's tested:Sham DeviceAuricular transcutaneous vagus nerve stimulation

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Dizziness Handicap Inventory (DHI) score
Measured over Baseline, 4 weeks

Conditions

Chronic Dizziness
Persistent Postural Perceptual Dizziness

Explore related trials

Persistent postural perceptual dizziness

Where it's being run

1 sites across 1 states
Florida1

Study leadership

  • Colton Clayton, Au.D., Ph.D. · PRINCIPAL_INVESTIGATOR · Mayo Clinic

Who to contact

Colton Clayton, Au.D., Ph.D.
[email protected]
904-953-2945
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Age 18-75, Persistent Postural-Perceptual Dizziness (PPPD) diagnosis per International Classification of Vestibular Disorders (ICVD).
Persistent dizziness ≥3 months and at least 1 dizziness exacerbation/day during 2-week run-in.
On stable medications/therapy for ≥4 weeks prior to baseline (if any).

Exclusion

Uncompensated peripheral/central vestibular deficit, sensory-afferent or cerebellar ataxia.
Cardiac disease (coronary disease, unstable arrhythmia), recurrent syncope (\>1 in past 12 months).
Neck surgery, vagotomy, or any condition interfering with vagal stimulation.
Pregnancy.

What this trial measures

  • Change in Dizziness Handicap Inventory (DHI) scoreBaseline, 4 weeks

    The Dizziness Handicap Inventory (DHI) is a 25-item questionnaire assesses physical, emotional, and functional aspects of dizziness. Each of the 25 questions has three answers: "Always" (4 points), "Sometimes" (2 points), or "No" (0 points). Scores are summed for a total from 0 (no disability) to 100 (maximum disability).