This study is looking at whether a combination of two thyroid hormones, levothyroxine (LT4) and liothyronine (LT3), works better than LT4 alone for people with primary hypothyroidism. You might be able to join if you are 18-70 years old, have hypothyroidism, and are currently taking LT4 but still have symptoms even though your TSH (thyroid stimulating hormone) levels are within the normal range. The study will measure your quality of life using a special questionnaire after 6 months to see if the combination therapy helps reduce your symptoms.

Study design

This is an interventional study planning to enroll 60 participants. You will either receive LT4 plus LT3 or LT4 plus a placebo (an inactive pill that looks like LT3).

What's involved

You will take either LT4+LT3 or LT4+placebo for 6 months. You will visit the clinic at the beginning and end of the study for blood tests and to answer questionnaires, and have blood tests at 6 and 13 weeks with weekly to monthly symptom checks by text.

Compensation

Not stated in the trial record.

Follow-up

Your quality of life will be measured at 6 months after starting the study treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.