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Project Q: Helping Light Smokers Quit

This study, called Project Q, is looking at new ways to help people who smoke lightly or not every day to quit. It tests a treatment called "Cue-based treatment intervention" alongside Cognitive Behavioral Therapy (CBT), which is a type of talk therapy. You might receive CBT alone or CBT plus the cue-based treatment, which helps you learn coping strategies when you encounter things that make you want to smoke. The study wants to see if these treatments are practical and acceptable for people to use from home. To join, you need to be at least 18 years old, smoke 1-10 cigarettes most days, and be willing to try quitting soon. The study is currently recruiting about 60 participants.

Study design
This study is interventional and will randomly assign participants to one of two groups: CBT only or CBT plus cue-based treatment. It aims to enroll 60 participants.
What's involved
You would participate in telehealth sessions and receive supportive text messages. You would also respond to real-time data collection and take pictures of situations where you smoke or crave cigarettes.
Compensation
Not stated in the trial record.
Follow-up
You would have assessments at the end of treatment, and then again at 6 months and 12 months after treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07425119

Project Q: Cue-based Treatment Intervention to Promote Cessation Among People Who Smoke Lightly or Non-daily

Recruiting
NAAges 18+InterventionalTreatment
Duke University
~60 participants
Updated 2026-07-28 on ClinicalTrials.gov
What's tested:Cognitive Behavioral Therapy (CBT)Cue-based treatment intervention

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Feasibility as measured by the number of participants who are recruited and randomized
Measured over During the recruitment period (up to 9 months)
+7 more outcomes measured

Conditions

Tobacco Use Disorder

Explore related trials

Smoking CessationTobacco Use Disorder

Where it's being run

1 sites across 1 states
North Carolina1

Study leadership

  • Laura Fish · PRINCIPAL_INVESTIGATOR · Duke University

Who to contact

Laura Fish, PhD
[email protected]
919-681-3820
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Age ≥18
Able to read and understand English or Spanish
Smoke 1-10 cigarettes/day on at least 4 days of the past two weeks for the last year
Willing to try quitting in next 30 days
Access to cell phone with texting capabilities

Exclusion

Current participation in another smoking cessation study
Unable to provide consent
Refusal to abstain from e-cigarettes or other tobacco products
Use of medications affecting smoking cessation (e.g., Chantix, Wellbutrin)

What this trial measures

  • Feasibility as measured by the number of participants who are recruited and randomizedDuring the recruitment period (up to 9 months)
  • Feasibility as measured by the number of participants who respond to pre-quit real-time data collectionEnd of treatment (up to 12 months)
  • Feasibility as measured by the number of participants who take pictures of smoking/craving situationsEnd of treatment (up to 12 months)
  • Feasibility as measured by the number of participants who complete all CBT (cognitive behavioral therapy) sessionsEnd of treatment (up to 12 months)
  • Feasibility as measured by the number of participants who complete all cue-based treatment sessionsEnd of treatment (up to 12 months)
  • Feasibility as measured by the number of participants who respond to EMA text based assessmentsEnd of treatment (up to 12 months)
  • Feasibility as measured by the number of participants who proactively text to report cravingsEnd of treatment (up to 12 months)
  • Acceptability of CBT + cue-based treatment intervention compared to CBT onlyEnd of treatment (up to 12 months)

    We will assess acceptability quantitatively and qualitatively. We will assess message helpfulness (1=Not at all helpful to 5=extremely helpful) and whether participants would recommend the program to a friend (1=definitely would not recommend to 5=definitely would recommend). We will also assess participant fidelity to the intervention protocol (e.g., experienced cues and texted to report when experiencing a cue). Qualitative data will be used to describe barriers and facilitators to intervention uptake among participants in the CBT + cue-based treatment arm.