Optic Nerve Head Strain in Non-Glaucoma Subjects

This study is looking at how the optic nerve (the nerve that connects your eye to your brain) responds to changes in eye pressure in people who do not have glaucoma. You might be able to join if you are an adult between 30 and 90 years old, have no history of open-angle glaucoma, and have normal eye exam results. Participants will take a daily eye drop called Latanoprost (0.005%) for less than one month. Researchers will take pictures of your optic nerve before and after you start the eye drops. The main goal is to measure the "strain" (how much the nerve changes shape) in your optic nerve over this one-month period. The study status is currently unclear.

Study design: This is an interventional study with a planned enrollment of 30 participants. It is not specified if it is randomized or blinded.
What's involved: You would have pictures taken of your optic nerve before and 2 weeks after starting a daily eye drop. You will take the Latanoprost (0.005%) eye drop daily for less than one month.
Compensation: Not stated in the trial record.
Follow-up: The primary endpoint is measured at up to 1 month after starting the eye drops.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

Optic Nerve Head Strain in Non-glaucoma Subjects

Recruiting

EARLY_PHASE1Ages 30–90InterventionalDiagnostic

Johns Hopkins University

~30 participants

Updated 2026-07-13 on ClinicalTrials.gov

What's tested:Latanoprost (0.005%)

At a glance

Recruiting sites

1 of 1 listed site is recruiting right now

RecruitingSuspended, closed, or not yet open

What they're measuring

Optic nerve head strain

Measured over up to 1 month

Conditions

Glaucoma

Where it's being run

1 sites across 1 states

Maryland1

Study leadership

Harry Quigley, MD · PRINCIPAL_INVESTIGATOR · Johns Hopkins University

Who to contact

Harry A Quigley, MD

[email protected]

410 955 6051

Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Adults who have no history of OAG

Have an ocular examination by a glaucoma specialist with no indications of OAG

Have normal optical coherence tomography findings in the retinal nerve fiber layer.

Over age 30 will be included from

Both sexes

All ethnic groups.

Optic neuropathy.

Both suspects and those with glaucoma damage will be included.

Exclusion

in whom sitting in an upright position is impossible due to physical disability

with ocular media opacity, corneal scarring, cataract or vitreous hemorrhage, that does not allow adequate imaging resolution.

in whom keeping the eyes open during the imaging procedure is not possible or uncomfortable.

who cannot perform home tonometry accurately at certification

who do not have reliable clinical Optical Coherence Tomography (OCT) testing.

with any form of glaucoma

with high myopia defined as refractive error \> -8

with past keratorefractive surgery, corneal dystrophy, or corneal ectasia that would make self-tonometry measurements difficult to interpret

inability to understand English or with a language or hearing impairment

What this trial measures

Optic nerve head strainup to 1 month
Biomechanical strain measured by optical coherence tomography

Trialytics