ROPES Study: Reducing Opioid Use After Prostatectomy

This study, called ROPES, is looking at ways to reduce the amount of opioid pain medication men need after robotic-assisted laparoscopic prostatectomy (RALP), a surgery to remove the prostate. Researchers are comparing different pain management plans after surgery. One plan includes a small opioid prescription right away, while another uses a multimodal analgesia pathway (a combination of pain relief methods) without an automatic opioid prescription, but you can call for opioids if needed. They are also looking at how much opioid was used before these new plans were put in place. The main goal is to see if these new approaches can lower the amount of opioids used after you leave the hospital. Men aged 45 and older undergoing RALP at Brigham and Women's Hospital or Brigham & Women's Faulkner Hospital can join, as long as they don't have certain health conditions like chronic kidney disease or regular opioid use. The study is currently unclear on its recruitment status.

Study design
This is an interventional study planning to enroll 300 men. It is an open-label, randomized study, meaning both you and your doctors will know which treatment group you are in.
What's involved
You would be counseled on post-operative pain management and then randomized to one of the pain management pathways after your robotic-assisted laparoscopic prostatectomy.
Compensation
Not stated in the trial record.
Follow-up
Your opioid consumption will be measured 1-2 weeks after surgery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07427043

Robotic Opioid-free Prostatectomy Enhanced Strategy (ROPES)

Recruiting
PHASE3Ages 45+InterventionalHealth services
Brigham and Women's Hospital
~300 participants
Updated 2026-05-22 on ClinicalTrials.gov
What's tested:multimodal analgesia pathway with up-front small opioid prescriptionmultimodal analgesia pathway without up-front small opioid prescriptionpre-implementation baseline including opioid

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Post-discharge opioid consumption (MME)
Measured over 1-2 weeks after surgery
Opioid Consumption, Postoperative
Multimodal Analgesia
Robotic Assisted Laparoscopic Surgery
Robotic Assisted Laparoscopic Radical Prostatectomy
Prostate Cancer
2 sites across 1 states
Massachusetts2
  • Timothy Clinton, MD · PRINCIPAL_INVESTIGATOR · Brigham and Women's Hospital

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Men ≥45 years old
Undergoing Robotic Assisted Laparoscopic Prostatectomy (RALP) at BWH or BWFH
Able to provide informed consent

Exclusion

Chronic kidney disease (baseline Cr \>1.3)
NSAID contraindication/allergy
Regular opioid use or substance abuse prior to surgery
Inability to provide their own consent
Deviation from standard surgical practice for RALP (e.g. major complication requiring operative intervention that would result in patient no longer being considered a routine case)
  • Post-discharge opioid consumption (MME)1-2 weeks after surgery

    assessed at post-operative visit