This study is looking at how different rehabilitation methods might help healthy adults before they use noninvasive mechanical ventilation (MV). MV is a breathing support machine. Sometimes, MV can weaken the diaphragm, your main breathing muscle. Researchers want to see if rehabilitation, like inspiratory strength training (IST) or transcutaneous spinal stimulation (TSCS), can help keep your diaphragm strong. You would have your breathing strength measured before and after using MV. This study is for non-smokers, aged 25 to 80, who are generally healthy and don't have certain lung conditions or other serious illnesses. The goal is to see if these rehabilitation methods can improve diaphragm function.

Study design

This interventional study plans to enroll 16 healthy adults. It will test different rehabilitation interventions, including inspiratory strength training (IST), transcutaneous spinal stimulation (TSCS), or sham TSCS.

What's involved

Participants will complete breathing strength tests and responses to phrenic nerve stimulation before and after mechanical ventilation. The primary breathing strength measurements are taken at baseline, 2 hours after MV, and 24 hours after MV.

Compensation

Not stated in the trial record.

Follow-up

Your breathing strength will be measured up to 24 hours after mechanical ventilation.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.