Amygdala Insula Retraining for Perimenopause Symptoms

This study is looking at a mind-body brain retraining program called Amygdala and Insula Retraining (AIR) for women experiencing perimenopause symptoms. Perimenopause is the time leading up to menopause, often causing sleep problems, fatigue, and mood changes. Researchers want to see if AIR can reduce these symptoms compared to a group that doesn't receive the program right away. They will measure your symptoms using a Menopause Rating Scale (MRS) at the beginning and after 12 weeks. You may be able to join if you are a woman between 38 and 60 years old, have perimenopausal symptoms, can read English, and have internet access. The study is currently unclear about its recruitment status.

Study design
This is a randomized, wait-list-controlled study with at least 160 participants. Participants will be assigned by chance to either receive the AIR program or be on a waiting list.
What's involved
Participants in the active group will receive a 12-week AIR program. The study duration is 24 weeks.
Compensation
Not stated in the trial record.
Follow-up
The primary symptom measurement is taken at 12 weeks (post-intervention).

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NCT07427459

Amygdala Insula Retraining in the Management of Perimenopause Symptoms

Recruiting
NAAges 38–60InterventionalTreatment
Chronic Conditions Research Fund
~160 participants
Updated 2026-06-29 on ClinicalTrials.gov
What's tested:Amygdala and Insula Retraining (AIR)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Menopause Rating Scale (MRS) Total Score
Measured over Baseline (Week 0) to post-intervention (Week 12)
Perimenopause
Menopausal Complaints
1 sites across 1 states
Iowa1

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Experiencing perimenopausal symptoms
Meets STRAW+10 criteria based on self-assessment (-2 to +1c)
Able to read and understand English
Access to internet

Exclusion

Pregnancy
Presence of a severe psychiatric condition requiring immediate clinical intervention
Uncontrolled thyroid disease or prolactinoma
Active cancer treatment
Inability to provide informed consent
Any medical or psychiatric condition that, in the judgment of the investigator or study team, would interfere with safe participation or study completion
  • Menopause Rating Scale (MRS) Total ScoreBaseline (Week 0) to post-intervention (Week 12)

    Overall perimenopausal symptom burden as measured by the Menopause Rating Scale (MRS). Scale: none (0)/extremely severe (4) - higher means worse outcome