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Oxytocin for Recovery After Total Hip Arthroplasty

This study is looking at whether intravenous (IV) oxytocin can help people recover faster after total hip arthroplasty (THA), which is a type of hip replacement surgery. You might be able to join if you are between 18 and 75 years old, are scheduled for a first-time hip replacement on one side, and are generally in good health. Participants will receive either oxytocin or a placebo (a salt water solution) through an IV for 45 minutes. The main goal is to see if oxytocin leads to more daily steps over 56 days after surgery, which would show faster recovery. The study's current status is unclear.

Study design
This is a randomized study where 80 participants will be assigned to receive either oxytocin or a placebo. It is "triple-masked," meaning you, your doctors, and the researchers won't know which treatment you receive.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your daily steps will be measured for 56 days after your surgery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07430228

Efficacy of Intravenous Oxytocin to Speed Recovery After THA

Enrolling by Invitation
PHASE2Ages 18–75InterventionalBasic science
Wake Forest University Health Sciences
~80 participants
Updated 2026-08-27 on ClinicalTrials.gov
What's tested:intravenous administration of oxytocinPlacebo

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Modeled daily steps trajectory
Measured over 56 days after surgery

Conditions

Total Hip Arthroplasty

Explore related trials

Total replacement of hip

Where it's being run

1 sites across 1 states
North Carolina1

Study leadership

  • Douglas Ririe, M.D. · PRINCIPAL_INVESTIGATOR · Wake Forest University School of Meidcine

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Male or female \> 18 and ≤75 years of age
Scheduled for unilateral, primary total hip arthroplasty surgery
Generally in good health as determined by the Principal Investigator based on prior medical history, and as assessed to be American Society of Anesthesiologists physical status 1, 2, or 3
Willing to perform the study procedures
Able to read and write English and have a stable residence.

Exclusion

Hypersensitivity to any ingredient in Pitocin® (marketed preparation of oxytocin for parenteral injection)
Latex allergy
Any disease, diagnosis, or condition (medical or surgical) that, in the opinion of the Principal Investigator, would place the participant at increased risk (e.g., active gynecologic disease in which increased tone would be detrimental such as uterine fibroids with ongoing bleeding)
Women who are pregnant, are currently nursing or lactating, or have been pregnant within 2 years
Current or history of ventricular tachycardia, atrial fibrillation or prolonged QT interval.
Past or current history of hyponatremia or at risk for hyponatremia; anyone taking thiazide diuretics, loop diuretics, combination diuretics, lithium, carbamazepine, enalapril, ramipril, celecoxib, temazepam, gliclazide, glimepiride, glibenclamide, glipizide, omeprazole, pantoprazole, desmopressin, Selective Serotonin Reuptake Inhibitors (SSRI's), Monoamine oxidase inhibitors (MAOIs), or the recreational drug ecstasy.
Inability to complete questionnaires
Litigation or workers compensation related to their joint surgery
Taking \> 100 mg morphine equivalents/day
Suffering from a psychotic disorder or a recent psychiatric hospitalization

What this trial measures

  • Modeled daily steps trajectory56 days after surgery

    Individual trajectories, adjusted for prognostic covariates, of daily steps will be constructed using an intercept on the first postoperative day and a slope a log of time dimension through day 56 using growth curve modeling. The intercept is in units of steps on the first post-discharge day with the lower number of steps indicating more disability and the slope is in units of logarithm of steps per day with the lower number indicating slower recovery from disability - Key models often classify adults into sedentary (\<5,000 steps), low active (5,000-7,499), somewhat active (7,500-9,999), or active (≥10,000) trajectories.