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Finger Plethysmography for Fluid Responsiveness in Pregnancy

This observational study is looking at a noninvasive (no needles or surgery) way to predict how a pregnant woman's body will respond to fluids. Researchers are comparing two methods: noninvasive finger plethysmographic cardiac output monitoring and standard transthoracic echocardiographic assessment (an ultrasound of the heart). The goal is to see if finger plethysmography can accurately predict changes in cardiac output (how much blood your heart pumps) when a woman's legs are raised, which helps doctors understand fluid responsiveness. This study includes healthy pregnant women and those with severe preeclampsia (high blood pressure and other issues during pregnancy). The study aims to enroll 88 women.

Study design
This is an observational study, meaning researchers will watch and record information without giving a specific treatment. It plans to include 88 participants.
What's involved
You would provide consent, undergo noninvasive heart monitoring, and participate in a brief, reversible physical challenge (like raising your legs).
Compensation
Not stated in the trial record.
Follow-up
Researchers will measure changes at baseline (when you're semi-reclined) and 1 minute after your legs are raised.

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NCT07430254

Finger Plethysmography to Predict Fluid Responsiveness in Healthy Pregnancy and Severe Preeclampsia

Not Yet Recruiting
Not specifiedAges 18+Observational
Stanford University
~88 participants
Updated 2026-02-24 on ClinicalTrials.gov
What's tested:Noninvasive finger plethysmographic cardiac output monitoringStandard transthoracic echocardiographic assessment

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Prediction Accuracy for Change in Cardiac Output for Fluid Responsiveness
Measured over Baseline (semi-recumbent) and 1 minute after passive leg raising

Conditions

Pre-Eclampsia, Severe
Pregnancy

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PreeclampsiaPregnancy

Where it's being run

1 sites across 1 states
California1

Who to contact

Study Team
[email protected]
(650) 723-5403
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Women diagnosed with preeclampsia with severe features following ACOG recommendations (systolic/diastolic BP \>160/110 mmHg, proteinuria, or other severe features like headaches, visual disturbances, kidney/liver impairment, thrombocytopenia).
Healthy pregnant women at term (for comparison group, e.g., scheduled for elective Cesarean delivery).

Exclusion

Patients who can not provide written consent to participate in the study
BMI greater than 40 kg/m²
Multiple pregnancy (twins, triplets, etc.)
Non-reassuring fetal heart tracing
≤ 22 weeks gestation
History of chronic arterial hypertension
Chronic kidney disease
Congenital or known acquired heart disease
Chronic obstructive pulmonary disease
Diabetes
History of stroke
Not tolerating passive leg raising (unable to be placed in the required study position)
No TTE-windows
Withdrawing consent
Emergency cesarean delivery

What this trial measures

  • Prediction Accuracy for Change in Cardiac Output for Fluid ResponsivenessBaseline (semi-recumbent) and 1 minute after passive leg raising

    Prediction accuracy (ROC-AUC) of percent change in cardiac output measured by noninvasive finger plethysmographic device during passive leg raising to identify fluid responsiveness (TTE reference)