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Buprenorphine for Pain in Older Adults with Fractures

This study is looking at whether buprenorphine can effectively treat pain in older adults (age 65 and older) who have broken bones. Researchers want to see if buprenorphine works as well as hydromorphone, another pain medication, but with fewer side effects. If you join, you would receive either buprenorphine or hydromorphone after a fracture. The study will then compare your pain scores and any side effects over 48 hours. The main goal is to find out if buprenorphine can improve pain control for older adults in the emergency room.

Study design
This interventional study plans to enroll 48 participants. It will compare buprenorphine to hydromorphone for pain relief.
What's involved
Participants will receive one of the study drugs and have their pain scores and side effects monitored for 48 hours.
Compensation
Not stated in the trial record.
Follow-up
Pain scores and side effects will be measured for 48 hours after receiving the study drug.

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NCT07430345

Buprenorphine for Analgesia in Older Adults With Acute Fractures in the Emergency Department

Recruiting
PHASE1Ages 65+InterventionalTreatment
The Cooper Health System
~48 participants
Updated 2026-06-29 on ClinicalTrials.gov
What's tested:Buprenorphine 0.15 MGHydromorphone 0.25 mg IV

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Difference in pain scores
Measured over 4 hours

Conditions

Fracture

Explore related trials

Fracture

Where it's being run

1 sites across 1 states
New Jersey1

Who to contact

Katherine E Selman, MD
[email protected]
856-342-2627
Email the study team

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Eligibility criteria

Inclusion

Age 65 years or older
Emergency Department patient
Diagnosis of suspected or confirmed acute fracture
Numerical Rating Scale 4 or greater at time of presentation
Must be able to give informed consent or have a surrogate decisionmaker to provide informed consent
Subjects who may require a surgical procedure are eligible for enrollment, as given the low dose of buprenorphine, this is not anticipated to affect future anesthesia. If additional pain control is needed for surgical procedure, full agonist opioid can be used without contraindication.

Exclusion

Prior history of opioid use disorder
Participants taking chronic opioid therapy (defined as opioids taken during the past month)
Allergy to study medications
Hemodynamic instability requiring immediate resuscitation
Inability to consent and absence of surrogate decisionmaker

What this trial measures

  • Difference in pain scores4 hours

    Difference in pain scores measured on the numerical rating scale (scale of 0-10, with 10 being maximum pain and 0 being no pain), collected on arrival and measured at one hour and four hours after medication administration