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Exercise and Carotid Artery Function in Metabolic Syndrome

This study is looking at how a single session of exercise affects blood vessel function in young adults with metabolic syndrome. Researchers want to see if people with metabolic syndrome (a group of risk factors that increase your chance of heart disease, stroke, and diabetes) have problems with their carotid artery (a major blood vessel in your neck) and if a 30-minute bike ride can help. They will compare 48 young adults, some with metabolic syndrome and some healthy, to understand these effects. The study aims to see if exercise can quickly improve blood vessel function and if there are differences between men and women. Your eligibility depends on your age (18-40) and specific health measures like waist size, cholesterol, blood pressure, and blood sugar.

Study design
This is an observational study involving 48 participants, comparing young adults with and without metabolic syndrome. It is not specified if the study is randomized or blinded.
What's involved
You would participate in approximately 5.5 hours of study activities spread across 4 visits. This includes a 30-minute cycling exercise, diagnostic tests like Doppler Ultrasound, and breathing different gas mixtures.
Compensation
Not stated in the trial record.
Follow-up
Your carotid artery function will be measured during exercise and at 10 and 60 minutes after exercise.

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NCT07430839

Exercise and Carotid Artery Function in Metabolic Syndrome

Recruiting
Not specifiedAges 18–40Observational
University of Wisconsin, Madison
~48 participants
Updated 2026-03-25 on ClinicalTrials.gov
What's tested:exerciseDiagnosticsInhaled CO2-mixed air

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Aim 1: Baseline ICA cSMD measures assessed by MetSyn versus healthy controls
Measured over baseline
+2 more outcomes measured

Conditions

Metabolic Syndrome

Explore related trials

Metabolic Syndrome

Where it's being run

1 sites across 1 states
Wisconsin1

Study leadership

  • William Schrage, PhD · PRINCIPAL_INVESTIGATOR · University of Wisconsin, Madison

Who to contact

Shawn Bolin, MS
[email protected]
608-263-6308
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Waist circumference greater than 102 cm (males) or 82 cm (females)
Triglycerides over 150 mg/dL
HDL cholesterol less than 40 mg/dL (males) or 50 mg/dL (females)
Blood pressure ≥130/85 mmHg
Fasting plasma glucose over 110 mg/dL

Exclusion

Current smoker, defined as more than 5 cigarettes over past 30 days
Current diagnosis or history of:
peripheral vascular disease
hepatic disease
renal disease
lung disease
gastrointestinal disorders/bleeding
hematologic disease
stroke
myocardial infarction
coronary heart disease
congestive heart failure
heart surgery
sleep apnea
autoimmune diseases
traumatic brain injury, concussion, stroke, or seizures
Asthma
Polycystic ovarian syndrome
Type II diabetes
Currently pregnant or breastfeeding
Current musculoskeletal injury Medication use known to influence cardiovascular function, other than oral contraceptives
Hormonal contraceptive use, such as intrauterine device or hormonal implant use
Participants with ICAs unsuitable for imaging, as assessed during the screening visit via doppler ultrasonography
BMI greater than 25 kg/m2
Blood pressure over 125/80 mmHg
Meeting any MetSyn criteria listed for MetSyn cohort

What this trial measures

  • Aim 1: Baseline ICA cSMD measures assessed by MetSyn versus healthy controlsbaseline

    Internal carotid artery cerebral shear-mediated dilation (cSMD) is measured by doppler ultrasound and reported in percentage increase in diameter. A resting baseline period for 5 minutes breathing room air followed by 30 seconds of breathing CO2-mixed air at +9 mmHg PETCO2 used to evoke an increase in blood flow to the ICA.

  • Aim 2: Baseline ICA cSMD measures assessed by MetSyn versus sexbaseline

    Internal carotid artery cerebral shear-mediated dilation is measured by doppler ultrasound and reported in percentage increase in diameter. A resting baseline period for 5 minutes breathing room air followed by 30 seconds of breathing CO2-mixed air at +9 mmHg PETCO2 used to evoke an increase in blood flow to the ICA.

  • Aim 3: Post-exercise cSMD response by MetSyn versus healthy controlsmeasured during exercise and 10 and 60 minutes post-exercise

    Internal carotid artery cerebral shear-mediated dilation is measured by doppler ultrasound and reported in percentage increase in diameter. 30 minutes of exercise on a cycle ergometer will be performed at 80% of the ventilatory threshold determined during the graded exercise test.