This study is looking into how your genes and environment affect your body weight by studying brain inflammation. Researchers want to see if identical twins with different eating habits have different body fat and brain inflammation. They also want to understand if your genes change how your brain reacts to specific diets. The study involves two parts. In one part, twins with different eating habits will have an MRI, body measurements, blood tests, and answer questions. In the other part, a different set of twins will be provided all their meals for two weeks, with some days being high-calorie and other days low-calorie, and will have similar tests. This study is for people aged 20-45 who are part of the Washington State Twin Registry and are willing to follow specific diet plans. The study is currently unclear on its recruitment status and plans to enroll 110 participants.

Study design

This is an interventional study involving two parts, each with different sets of twin participants. The study aims to enroll 110 participants.

What's involved

Participants in Study 1 will have one in-person visit. Participants in Study 2 will have three in-person visits over two weeks, during which all meals will be provided by the study.

Compensation

Not stated in the trial record.

Follow-up

Hypothalamic Gliosis is measured at enrollment for Study 1 and at 7 days of diet intervention for Study 2.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.