Back to search results

Understanding Brain Changes in Cerebral Palsy

This study aims to better understand how the brains of people with cerebral palsy (CP) change over time. While CP is defined as a non-progressive brain injury from early childhood, many adults with CP experience a decline in their abilities. Researchers want to see if these changes are linked to brain and spinal cord shrinkage (atrophy) that could suggest neurodegeneration. They will do this by looking at existing brain and spinal cord MRI scans from adults with CP across the United States. You might be able to participate if you are between 18 and 80 years old, have a diagnosis of CP, and have had at least two brain or spinal cord MRI scans at least two years apart, with one scan after age 18. The main goal is to measure changes in total brain volume over time.

Study design
This is an observational study, meaning researchers will look at existing medical information rather than giving new treatments. It plans to include 30 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The study will look at changes in brain volume over at least two years, comparing your first and second MRI scans.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07433647

Evaluation of Brain MRI Changes in Cerebral Palsy Patients

Recruiting
Not specifiedAges 18–80Observational
Columbia University
~30 participants
Updated 2026-05-13 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Total brain volume
Measured over From first MRI scan to second MRI scan, composed of a timespan of at least 2 or more years

Conditions

Cerebral Palsy
Spastic Diplegia
Spastic Quadriplegia
Spastic Hemiplegia

Explore related trials

Cerebral PalsySpastic DiplegiaSpastic HemiplegiaSpastic Quadriplegia

Where it's being run

1 sites across 1 states
New York1

Study leadership

  • Jason Carmel, MD, PhD · PRINCIPAL_INVESTIGATOR · Columbia University

Who to contact

Jason Carmel, MD, PhD
[email protected]
212-305-2700 · ext. 3
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Have multiple MRI scans of brain and/or spinal cord spaced at least 24 months apart
Between 18-80 years of age with at least one MRI scan after the age of 18
No known central or peripheral neurological disease or injury other than cerebral palsy causing brain degeneration
Inclusion in CPRN registry
diagnosis of Cerebral Palsy
\>18 years of age
Have received at least one past brain MRI scan as part of standard care (patients who have two or more brain MRI scans can be included in the retrospective arm only)

Exclusion

History of more than one seizure in lifetime
History of known degenerative genetic disorder
History of brain tumor, abscess, or multiple sclerosis
History of moderate or severe head trauma
History of metal implants in head

What this trial measures

  • Total brain volumeFrom first MRI scan to second MRI scan, composed of a timespan of at least 2 or more years

    This is a number, measured in cubic millimeters, that includes the output from segmentation of each individual MRI scan per subject.