Image-Guided DBS Programming for Essential Tremor

This study is comparing two ways to program your Deep Brain Stimulation (DBS) device for Essential Tremor (ET): standard clinical programming versus image-guided programming. The goal is to see which method is better at reducing tremor and making patients more satisfied. You might be able to join if you are between 21 and 85 years old, have ET, and already have a Boston Scientific DBS device implanted in the VIM thalamus (a part of the brain). The main way success will be measured is by how much your tremor severity (how strong your tremor is) improves after one month, using a device called an accelerometer. The study is currently unclear on its recruitment status and plans to enroll 20 participants.

Study design
This interventional study will compare two different programming methods for DBS in 20 participants with Essential Tremor.
What's involved
You will have an initial visit where your DBS device is temporarily turned off for baseline assessments. You will then experience both programming settings, with tremor assessments for each, and then use one setting for a week, switch to the other for a week, and then choose your preferred setting for two more weeks.
Compensation
Not stated in the trial record.
Follow-up
Tremor severity will be measured at 1 Month after the initial visit.

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NCT07433699

Image-Guided DBS Programming

Not Yet Recruiting
NAAges 21–85InterventionalTreatment
University of Pennsylvania
~20 participants
Updated 2026-08-06 on ClinicalTrials.gov
What's tested:programming aprogramming b

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Tremor severity as measured by accelerometry
Measured over 1 Month
Essential Tremor
1 sites across 1 states
Pennsylvania1

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Eligibility criteria

Inclusion

• Patients from 21-85 years of age
ET patients implanted with Boston Scientific DBS electrodes in the VIM thalamus
Proficiency with the English Language
Participant is able to comply with all testing and follow-up requirements as defined by the study protocol
Participant is able to provide voluntary decisionally capable, and appropriately informed consent
  • Tremor severity as measured by accelerometry1 Month

    1\. The Xsens MTw Awinda accelerometer will be used to measure tremor severity. Measurements will be taken at baseline (DBS off) and after each stimulation setting. The accelerometry data can be objectively measured by quantifying the frequency and amplitude of the tremors and has been shown to correlate with the CRST.