APPRAISE: Atropine for Pain and Posterior Synechiae Reduction After Eye Surgery

This study, called APPRAISE, is looking at whether atropine 1% eyedrops are helpful after certain eye surgeries. Atropine eyedrops are often used after these surgeries, and this study will compare outcomes in patients who either use or don't use them. The main goal is to see how much pain you experience, measured by a pain score (Visual Analog Scale or VAS) one month after surgery. You might be able to join if you are having vitrectomy surgery, are 18 or older, and can give informed consent. You cannot join if you have an allergy to atropine or are using certain other eyedrops. The current status of this study is unclear, and it plans to enroll 62 participants.

Study design
This is an interventional study comparing outcomes in patients who either use or don't use atropine eyedrops after surgery. It plans to enroll 62 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your pain score will be measured one month after surgery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07434635

APPRAISE: Assessment of Pain and Posterior Synechiae Reduction With Atropine, an Investigation of Post-Surgical Eyes

Recruiting
PHASE4Ages 18+InterventionalTreatment
University of California, San Francisco
~62 participants
Updated 2026-07-31 on ClinicalTrials.gov
What's tested:Atropine 1%

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Pain score on the Visual Analog Scale (VAS)
Measured over 1 month
Eye Disorders
1 sites across 1 states
California1
  • Jay Stewart, MD · PRINCIPAL_INVESTIGATOR · University of California, San Francisco

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

patient undergoing vitrectomy surgery
able to give informed consent

Exclusion

post-operative eyedrop regimens that include topical non steroidal anti-inflammatory medications
subjects with altered post-operative eyedrop schedule for enhanced inflammation control
documented allergy to atropine
  • Pain score on the Visual Analog Scale (VAS)1 month

    Whether atropine use impacts post-operative pain score on the standard Visual Analog Scale (VAS)