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Examining Buprenorphine and Oxycodone for Pain in Trauma Care

This study is looking at how well two pain medications, buprenorphine and oxycodone, work for people who have experienced a traumatic injury. Researchers want to see if bupuprenorphine, which is also used for opioid use disorder (OUD), can effectively manage pain. You might be able to join if you are an adult between 18 and 80 years old, have injuries to at least two parts of your body, and your Glasgow Coma Scale (GCS) score (a measure of consciousness) is 15 or improves to 15 within 24 hours of admission. The main goal is to compare pain scores using the Numeric Rating Scale (NRS) after 14 days. The current status of this study is unclear, and it plans to enroll 282 participants.

Study design
This is an interventional study, meaning participants will receive specific treatments. It aims to enroll 282 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your pain scores will be measured at Day 14.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07435077

Examining Analgesic Synergy and Efficacy in Trauma Care

Not Yet Recruiting
PHASE4Ages 18–80InterventionalTreatment
Wake Forest University Health Sciences
~282 participants
Updated 2026-08-28 on ClinicalTrials.gov
What's tested:BuprenorphineOxycodone

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
The Numeric Rating Scale (NRS) Pain Scores
Measured over Day 14

Conditions

Opioid Use Disorder

Explore related trials

Acute PainInjury

Where it's being run

1 sites across 1 states
North Carolina1

Study leadership

  • Matthew Painter, MD, FACS · PRINCIPAL_INVESTIGATOR · Wake Forest University Health Sciences

Who to contact

D'Ann B Hershel, MS
[email protected]
336-716-1659
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Adult patients with injury to at least 2 body locations as defined by Abbreviated Injury Scale (AIS) scores (Head, Face, Neck, Chest, Abdomen/Pelvis, Spine, Upper Extremity, Lower Extremity, External)

Exclusion

Glasgow Coma Scale (GCS) \<15 - Patients may be included if their GCS improves to 15 within 24 hours of admission
Age \<18 years
Age ≥80years
Prisoners
Pregnant patients
Non-English speakers
Inability to provide consent
Home buprenorphine or methadone use
Home opioid use \>45 Morphine Milligram Equivalents (MME)/day
Allergy to any medication within the study or control arm
Patients undergoing treatment for alcohol withdrawal
History of cirrhosis requiring dose adjustment of Tylenol

What this trial measures

  • The Numeric Rating Scale (NRS) Pain ScoresDay 14

    The Numeric Rating Scale (NRS) is an 11-point, self-reported measure of pain intensity ranging from 0 ("no pain") to 10 ("worst imaginable pain").