Understanding Puberty in Children with Obesity

This observational study is looking at how different factors, like genes, hormones, diet, and exposure to certain chemicals, might affect when puberty starts in children with obesity. Researchers want to understand what predicts early puberty in children aged 5 to 12 who have obesity. They will compare children who receive a weight loss intervention (like nutrition, behavioral therapy, and exercise) with those who do not. The main goal is to identify what causes puberty to start at a certain time in these children. The study plans to enroll 400 participants, but its current status is unclear.

Study design
This is an observational study, meaning researchers will watch and collect information without assigning specific treatments. It aims to enroll 400 participants.
What's involved
You would have clinic visits every 6 months until you reach age 12. Each visit will include a physical exam.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed every 6 months, or every 6-12 months at the investigator's discretion, until they reach age 12.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07437976

A Natural History of Genetic and Environmental Predictors of Pubertal Timing Among Youth With Obesity

Not Yet Recruiting
Not specifiedAges 5–12Observational
National Institute of Environmental Health Sciences (NIEHS)
~400 participants
Updated 2026-09-03 on ClinicalTrials.gov
What's tested:Weight loss interventionNo Weight loss intervention

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
To identify predictors of pubertal timing in 5-12-year-old children with obesity
Measured over 1. Every 6 months2. Every 6 - 12 months, investigator discretion
Obesity
1 sites across 1 states
North Carolina1
  • Natalie D Shaw, M.D. · PRINCIPAL_INVESTIGATOR · National Institute of Environmental Health Sciences (NIEHS)
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  • To identify predictors of pubertal timing in 5-12-year-old children with obesity1. Every 6 months2. Every 6 - 12 months, investigator discretion

    1\. pubertal markers by questionnaire, physical exam (testicular volume, Tanner breast staging), and 2. ultrasound (breast morphological stage).