Understanding Puberty in Children with Obesity
This observational study is looking at how different factors, like genes, hormones, diet, and exposure to certain chemicals, might affect when puberty starts in children with obesity. Researchers want to understand what predicts early puberty in children aged 5 to 12 who have obesity. They will compare children who receive a weight loss intervention (like nutrition, behavioral therapy, and exercise) with those who do not. The main goal is to identify what causes puberty to start at a certain time in these children. The study plans to enroll 400 participants, but its current status is unclear.
- Study design
- This is an observational study, meaning researchers will watch and collect information without assigning specific treatments. It aims to enroll 400 participants.
- What's involved
- You would have clinic visits every 6 months until you reach age 12. Each visit will include a physical exam.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed every 6 months, or every 6-12 months at the investigator's discretion, until they reach age 12.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
A Natural History of Genetic and Environmental Predictors of Pubertal Timing Among Youth With Obesity
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Natalie D Shaw, M.D. · PRINCIPAL_INVESTIGATOR · National Institute of Environmental Health Sciences (NIEHS)
Who to contact
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What this trial measures
- To identify predictors of pubertal timing in 5-12-year-old children with obesity1. Every 6 months2. Every 6 - 12 months, investigator discretion
1\. pubertal markers by questionnaire, physical exam (testicular volume, Tanner breast staging), and 2. ultrasound (breast morphological stage).