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Comparing Root Canal Disinfection Methods for Periapical Periodontitis

This study is comparing two ways to clean root canals in teeth with periapical periodontitis (an infection around the tooth root). It's testing a disinfection device using an Er,Cr:YSGG laser (2780 nm) and another method using ultrasonic activation. Researchers want to see which method is better at reducing bacteria in the root canal. You might be able to join if you are an adult between 18 and 70 years old, have a molar tooth needing a root canal, and have an infection around the tooth root. The main goal is to measure how much bacteria is reduced immediately after the cleaning procedure. The current recruitment status is unclear.

Study design
This interventional study plans to enroll 50 participants to compare two different disinfection protocols.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Bacterial levels will be measured immediately after the irrigation activation procedure, and qPCR analysis will be performed at the end of the study once all samples are collected.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07439614

Comparison of Root Canal Desinfection Protocols

Recruiting
NAAges 18–70InterventionalTreatment
State University of New York at Buffalo
~50 participants
Updated 2026-06-23 on ClinicalTrials.gov
What's tested:Desinfection deviceAnalytical microbiological methods

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Reduction of bacteria in the root canal system
Measured over Immediately after the irrigation activation procedure, ATP levels will be measured, and qPCR analysis will be performed at the end of the study, once all samples have been collected.

Conditions

Periapical Periodontitis

Explore related trials

Apical periodontitis

Where it's being run

1 sites across 1 states
New York1

Who to contact

Stephen Lyon, DDS
[email protected]
(716) 829-6229
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Adult patients able to give informed consent and willing/able to comply with study procedures and follow-up.
Molar teeth indicated for endodontic treatment.
Teeth with intact pulp-chamber walls (no extensive coronal destruction).
Necrotic pulp confirmed by pulp testing.
Clinical and radiographic evidence of asymptomatic apical periodontitis.

Exclusion

Immature teeth
Teeth with calcified or obliterated canals
Teeth with extensive coronal destruction
Teeth with previous endodontic treatment
Symptomatic apical periodontitis
Teeth with periodontal pockets greater than 4 mm
Patients who have received systemic antibiotics in the last 3 months
Patients with a history of diabetes or immune impairment
Pregnant patients

What this trial measures

  • Reduction of bacteria in the root canal systemImmediately after the irrigation activation procedure, ATP levels will be measured, and qPCR analysis will be performed at the end of the study, once all samples have been collected.

    Evaluation of the effectiveness of different irrigation activation devices by assessing bacterial reduction in the root canal system. ATP levels will be measured (Endoscore and RLU values) to provide a rapid assessment of bacterial load in less than one minute. Subsequently, bacterial reduction will be confirmed by quantitative polymerase chain reaction (qPCR) analysis