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Voice Analysis for Pulmonary Arterial Pressure Changes in Heart Failure

This study is looking at whether daily voice recordings can help detect changes in pulmonary arterial (PA) pressure in people with heart failure. You would use a mobile app called Noah Labs to record your voice daily for 12 weeks. This study is for adults aged 18 or older who have an implanted PA pressure sensor (like CardioMEMS or Cordella) and are willing to record their voice daily in English or German. The researchers will use computer programs (machine learning) to analyze your voice recordings and see if they can identify changes in your PA pressure. The main goal is to see how well this voice analysis can detect these pressure changes.

Study design
This is an observational study with a planned enrollment of 60 participants. It is looking at how voice analysis can detect changes in PA pressure.
What's involved
You would record daily voice samples (sustained vowels and a reading passage) using a smartphone app for 12 weeks. No additional clinical visits are required.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint for detecting PA pressure changes is measured at 12 weeks.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07443670

Voice Analysis to Detect Pulmonary Arterial Pressure Changes in Heart Failure

Recruiting
Not specifiedAges 18+Observational
Noah Labs
~60 participants
Updated 2026-03-02 on ClinicalTrials.gov
What's tested:Daily Voice Recording

At a glance

Recruiting sites
1 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Sensitivity of AI Voice Analysis in Detecting PA Pressure Changes
Measured over 12 weeks

Conditions

Heart Failure

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Heart Failure

NCT07443670

Where you'd take part

This study runs at 3 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • University of California, San Francisco (UCSF)

    San Francisco, Californiastudy coordinator listed

    Recruiting

  • BG Klinikum Unfallkrankenhaus Berlin, Dept. of Cardiology

    Berlin, State of Berlin, Germanyno site contact published

    Completed

  • University Hospital Frankfurt, Dept. of Cardiology and Angiology

    Frankfurt, Germanyno site contact published

    Completed

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Who to contact

Leonhard Riehle, MD
[email protected]
+491715547970
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

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Eligibility criteria

Inclusion

Age 18 years or older
Successful implantation of a PA pressure sensor and monitored by a participating study center
Willingness to record a short predefined text daily for 3 months using a smartphone or tablet
Ability to comfortably read aloud the study passage in English or German
Written informed consent obtained

Exclusion

Pregnant, breastfeeding, or unwilling to practice birth control during participation
Condition that in the opinion of the investigator would compromise patient safety or data quality
Pathological voice changes due to surgery or injury
Planned invasive cardiac procedures during the study period
COPD requiring home oxygen therapy
Chronic kidney disease requiring dialysis
Cognitive dysfunction limiting ability to perform daily voice recording
Inability to read English or German
Physical inability to use the recording device

What this trial measures

  • Sensitivity of AI Voice Analysis in Detecting PA Pressure Changes12 weeks

    Sensitivity and specificity of the AI-based voice analysis algorithm in detecting pulmonary arterial pressure changes at pre-specified thresholds.