Imaging for Parathyroid Tumors with 18F-Fluorocholine PET/MR and NeuroEXPLORER PET/CT
This study is looking at new ways to find parathyroid tumors before surgery. Parathyroid glands are small glands in your neck that can sometimes grow too large or develop tumors, requiring surgery. Researchers are testing if a special imaging scan called PET/MRI and a new PET/CT machine called NeuroEXPLORER, used with a tracer called 18F-FCH, can more accurately locate these tumors. The main goal is to see how well these imaging methods can pinpoint the tumors in people with primary hyperparathyroidism (PHPT), a condition where the parathyroid glands make too much hormone. You may be able to join if you are between 18 and 100 years old and are scheduled for parathyroid surgery at the NIH Clinical Center. The study status is currently unclear.
- Study design
- This is an interventional study planning to enroll 193 participants. It is not specified if the study is randomized or blinded.
- What's involved
- Participants will have up to 4 clinic or hospital visits. You will be screened to determine eligibility.
- Compensation
- Not stated in the trial record.
- Follow-up
- Not specified.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Accuracy of 18F-Fluorocholine PET/MR and NeuroEXPLORER PET/CT Imaging for Localization of Parathyroid Tumors
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Smita Jha, M.D. · PRINCIPAL_INVESTIGATOR · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Who to contact
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What this trial measures
- Evaluate positive predictive value of 18F-FCH PET/MRI and PET/CT in participants with sporadic primary hyperparathyroidism (PHPT)Positive predictive Value (PPV) of 18F-FCH PET/MRI and PET/CT in participants with sporadic primary hyperparathyroidism (PHPT)
Biochemical cure in conjunction with histological findings is the standard endpoint to confirm cure. Positive Predictive Value (PPV) is defined as the ability to distinguish between a true positive and a false positive
- Evaluate positive predictive value of 18F-FCH PET/MRI and PET/CT in participants with sporadic primary hyperparathyroidism (PHPT)Positive predictive Value (PPV) of 18F-FCH PET/MRI and PET/CT in participants with sporadic primary hyperparathyroidism (PHPT)
Biochemical cure in conjunction with histological findings is the standard endpoint to confirm cure. Positive Predictive Value (PPV) is defined as the ability to distinguish between a true positive and a false positive when considering only positive diagnostic assessments. Positive Predictive Value would help in assessing frequency of false positives: Positive predictive value = true positive/ \[true positives + false positives\]