Back to search results

Optimizing Weight Loss and Muscle Health in Older Adults

This study is looking for adults aged 50-75 who are overweight or have obesity to test different ways to help with weight loss and maintain muscle. You would join a 16-week group program focused on diet, either a high protein diet or a standard protein diet. If you don't meet certain weight loss goals after 8 weeks, you might also receive protein supplements or supervised exercise sessions. The main goals are to see how much weight you lose and how much lean muscle mass (fat-free mass) changes over time. The study aims to enroll 250 participants and is currently unclear about its recruitment status.

Study design
This is an interventional study designed as a Sequential Multiple Assignment Randomized Trial (SMART) with a planned enrollment of 250 participants.
What's involved
You would participate in 16 weeks of weekly group-based treatment, followed by 36 weeks of monthly group sessions. All sessions will be delivered via Zoom.
Compensation
Not stated in the trial record.
Follow-up
Your body weight and fat-free mass will be measured at baseline, 8 weeks, 16 weeks, and 52 weeks.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07446907

Optimizing Adaptive Intensive Behavioral Therapy for Obesity During the Transition to Older Adulthood

Not Yet Recruiting
NAAges 50–75InterventionalTreatment
University of Alabama at Birmingham
~250 participants
Updated 2026-08-03 on ClinicalTrials.gov
What's tested:High Protein Diet CouncelingStandard Protein Diet CouncelingProtein SupplementSupervised Exercise

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Body Weight
Measured over Baseline, 8 weeks, 16 weeks, 52 weeks
+1 more outcome measured

Conditions

Obesity & Overweight
Sarcopenia

Explore related trials

ObesitySarcopenia

Where it's being run

1 sites across 1 states
Alabama1

Study leadership

  • Drew Sayer, MD · PRINCIPAL_INVESTIGATOR · University of Alabama at Birmingham

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Male or female sex
all racial and ethnic groups
BMI: 30-50 kg/m2
age 50-75 years
postmenopausal status for ≥1 y if female sex

Exclusion

\<3 months stable use of other medications affecting body weight or appetite
\>450 pounds (due to weight limitations of the DXA)
indication or previous diagnosis of sarcopenia
existing kidney disease
current binge eating disorder, anorexia, or bulimia
untreated hyper- or hypothyroidism, cancer (except basal cell), gastrointestinal disorders affecting food intake or nutrient absorption; any other medical condition, as determined by the study physician, precluding a HP diet and/or daily exercise

What this trial measures

  • Change in Body WeightBaseline, 8 weeks, 16 weeks, 52 weeks

    Participants will be weighed at baseline through 52 weeks

  • Change in Fat Free MassBaseline, 8 weeks, 16 weeks, 52 weeks

    Participants will be scanned via DXA scan to measure overall fat free body mass