Proof-of-Concept Study Evaluating Total Body Weight, Physical Function & Safety of Enobosarm in Patients Treated With GLP-1 Receptor Agonist, for Weight Loss

{ "Enobosarm and Semaglutide for Weight Loss in Older Adults", "This study is testing if adding enobosarm to semaglutide (Wegovy), a common weight-loss medication, helps older adults lose more weight than semaglutide alone. Enobosarm is a drug that aims to increase muscle and reduce fat. We are looking for 200 participants aged 65 to 100 years old who are overweight or have obesity. Women must be postmenopausal. The main goal is to see how much total body weight changes after about 1.5 years (476 days) when combining enobosarm with semaglutide, compared to semaglutide alone. The study status is currently unclear.", "design": "This is a randomized, double-blind, and placebo-controlled study with 200 participants. You would be randomly assigned to receive either semaglutide plus enobosarm, or semaglutide plus a placebo (an inactive substance).", "commitments": "You would start semaglutide injections on Day 1. The study measures your body weight at 68 weeks (476 days).", "compensation": "Not stated in the trial record.", "follow_up": "There will be a safety follow-up visit about 30 days after your last dose of the study drug.", }

Study design
Not specified.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07446998

Proof-of-Concept Study Evaluating Total Body Weight, Physical Function & Safety of Enobosarm in Patients Treated With GLP-1 Receptor Agonist, for Weight Loss

Recruiting
PHASE2Ages 65+InterventionalTreatment
Veru Inc.
~200 participants
Updated 2026-07-01 on ClinicalTrials.gov
What's tested:EnobosarmSemaglutide (Wegovy) weekly injection

At a glance

Recruiting sites
13 of 14 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
To determine the effect of enobosarm in combination with semaglutide on total body weight compared to semaglutide alone.
Measured over Day 476
Obesity & Overweight
Mobility Disability
HOMA-IR
14 sites across 10 states
Florida5
Arizona1
Georgia1
Louisiana1
Maryland1
Mississippi1
New York1
North Carolina1
  • Barnette · STUDY_CHAIR · Veru Inc.

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Eligibility criteria

Inclusion

Subjects accepted for this study must:
one year or more of amenorrhea
surgical menopause with bilateral oophorectomy
Be premenopausal or perimenopausal with a negative pregnancy test.
If subject is of child bearing potential, the subject must agree to use acceptable methods of contraception: If female study participant could become pregnant, use acceptable methods of contraception from the time of the first administration of study medication until 30 days following administration of the last dose of study medication. Acceptable methods of contraception are as follows: Condom with spermicidal foam/gel/film/cream/suppository \[i.e., barrier method of contraception\], surgical sterilization of male partner (vasectomy with documentation of azoospermia) and a barrier method {condom used with spermicidal foam/gel/film/cream/suppository}, oral contraceptives (combination estrogen/progesterone pills), injectable progesterone or subdermal implants and a barrier method (condom used with spermicidal foam/gel/film/cream/suppository)
  • To determine the effect of enobosarm in combination with semaglutide on total body weight compared to semaglutide alone.Day 476

    To determine the effect of enobosarm in combination with semaglutide on total body weight compared to semaglutide alone.