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Improving Sleep in African American Couples Study (ISAAC) for Obstructive Sleep Apnea

The ISAAC study is looking for African American couples where one partner has moderate to severe obstructive sleep apnea (OSA). This study aims to see if a special program, including CPAP training for couples, virtual support groups led by other couples with OSA, and CPAP tele-monitoring with feedback, can help people use their CPAP machine more consistently. Another group will receive standard CPAP training. The main goal is to measure how much CPAP is used nightly after one year. You may be able to join if you are at least 30 years old, have moderate or severe OSA, and have a bed partner who has lived with you for at least six months and is willing to participate. The study is currently recruiting 440 participants.

Study design
This is a randomized study involving 220 African American patients with moderate to severe OSA and their bed partners. Participants will be assigned by chance to either receive standard CPAP care or a couple-oriented intervention.
What's involved
Participants will receive CPAP training and education, attend virtual support group sessions, and may participate in virtual cognitive behavioral couple therapy sessions. CPAP use will be monitored for one year.
Compensation
Not stated in the trial record.
Follow-up
Participants' nightly CPAP use will be measured from enrollment until one year.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07447284

The Improving Sleep in African American Couples Study (ISAAC)

Recruiting
NAAges 30+InterventionalTreatment
MetroHealth Medical Center
~440 participants
Updated 2026-08-27 on ClinicalTrials.gov
What's tested:CPAP Training and EducationVirtual Disease Support Group SessionsCouple CPAP Training and EducationCouples Virtual OSA Support Group SessionsCPAP Tele-monitoring and FeedbackCouples' Cognitive Behavioral Therapy

At a glance

Recruiting sites
1 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Mean Nightly CPAP Use at 1 Year
Measured over From enrollment until 1 year.

Conditions

Obstructive Sleep Apnea (OSA)

Explore related trials

Obstructive Sleep Apnea

Where it's being run

2 sites across 2 states
Ohio1
Pennsylvania1

Study leadership

  • John Thornton, MD, MPH · PRINCIPAL_INVESTIGATOR · MetroHealth System, Ohio

Who to contact

Marquisha Marbury
[email protected]
216-778-8484
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Moderate or severe OSA (Apnea hypopnea index ≥ 15 events/hour)
Age ≥ 30 years
Bed partner for ≥ last 6 months who is willing to participate
English proficient
Bed partner for ≥ 6 months and willing to participate
English proficient

Exclusion

Terminal illness
Neurocognitive disorder that prevents informed consent
Unstable housing
Need for other forms of positive airway pressure (BPAP or VPAP)
Pregnancy

What this trial measures

  • Mean Nightly CPAP Use at 1 YearFrom enrollment until 1 year.

    Mean CPAP use at year will be the total hours of CPAP use divided by the number of days observed for the patient over the course of a year.