This study is looking at how your body's immune system (IMMUNOTHERAPY) responds to cat allergens. We are testing an "intradermal cat allergen challenge," which involves injecting a small amount of cat allergen into your skin. We want to understand how your lymph nodes react to this challenge. We are looking for 16 participants, aged 18 to 45, who have moderate to severe cat allergies that affect their daily life or sleep. Eight participants will have already been on cat allergy shots (subcutaneous immunotherapy, or SCIT) for at least a year, and eight will have never had cat allergy shots. The main goal is to count the number of specific cells in your lymph nodes at Day 4 and Week 3 after the challenge.

Study design

This study is an interventional study with 16 participants. It compares two groups: those who have received cat allergy shots and those who have not.

What's involved

You will have a cat allergen challenge on Day 1. On Day 4, you will have lymph node and blood samples taken. On Week 3, you will have lymph node, blood, adenoid, and nasal samples taken.

Compensation

Not stated in the trial record.

Follow-up

Participants will be followed until Week 3 for lymph node, blood, adenoid, and nasal sampling.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.