Photobiomodulation for Itch Relief
This study is testing a device that uses near-infrared LED light, called Photobiomodulation (PBM), to see if it can safely and effectively reduce itching (pruritus). Researchers want to find out if this light, which doesn't break the skin or produce heat, can help lessen itch by affecting nerve signals. You might be able to join if you are an adult aged 18 or older and have had itch for less than 6 weeks (acute) or more than 6 weeks (chronic). The study will enroll 20 participants, and success will be measured by changes in your daily itch scores (Peak Pruritus Numerical Rating Scale). The current recruitment status is unclear.
- Study design
- This is an interventional study planning to enroll 20 participants. It compares the LED Photobiomodulation device to a placebo device.
- What's involved
- You would provide daily itch scores for 7 days before treatment, during each treatment visit, and for 7 days after the final treatment.
- Compensation
- Not stated in the trial record.
- Follow-up
- You will be asked to provide daily itch scores for 7 days after your final treatment visit.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Assessing the Efficacy and Safety of Photobiomodulation for the Treatment of Pruritus
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Richard R. Anderson, MD · PRINCIPAL_INVESTIGATOR · Massachusetts General Hospital
Who to contact
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What this trial measures
- Peak Pruritus Numerical Rating Scale (PP-NRS)Once daily for 7 days prior to the first treatment visit; each treatment visit; once daily for 7 days after the final treatment visit--Days -7~6, Days 13~20.
The primary endpoint is itch response, defined as a reduction of at least 2 points in the PP-NRS from baseline. The PP-NRS is an 11-point scale in which study participants are asked to rate their worst itch intensity during the previous 24 hours. Scores range from 0 to 10, with higher scores indicating more severe itch. 0 indicates no itch and 10 indicates the "worst itch imaginable." Participants will complete the PP-NRS daily and then we will calculate the average over 7 days preceding the study visit. Scores recorded at each treatment visit represent an average from the prior day. After the final treatment visit, participants will be asked again to complete a daily PP-NRS the next day, and then daily for the next 7 days. The score from the final treatment visit, as well as the average post-treatment score one week later will be compared to their average baseline score, with a change in PP-NRS from baseline by 2 or more representing a meaningful improvement.