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Cranberry Polyphenols and Stress Resilience Study

This study is looking at whether drinking cranberry juice daily can help healthy adults, aged 30-55, better handle stress and improve their ability to multitask. Participants will either drink cranberry juice or a placebo juice (a drink that looks and tastes like cranberry juice but has no active ingredients) every day for 70 days. Researchers will measure how well participants perform on cognitive tasks (like serial subtraction accuracy and errors) at the beginning and end of the study to see if cranberry juice helps with mental performance and reduces stress responses during challenging tasks. The study is currently unclear on its recruitment status.

Study design
This is a randomized, double-blind, placebo-controlled study with 84 healthy adults.
What's involved
You would have three in-person visits over 13 weeks and drink either cranberry juice or placebo juice daily for 70 days.
Compensation
Not stated in the trial record.
Follow-up
Your cognitive task performance will be measured at the beginning and end of the 70-day intervention period.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07453537

Cranberry Polyphenols and Stress Resilience During Multitasking in Healthy Adults

Recruiting
NAAges 30–55InterventionalBasic science
University of Florida
~84 participants
Updated 2026-06-30 on ClinicalTrials.gov
What's tested:Cranberry juicePlacebo juice

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Cognitive task performance (serial subtraction accuracy)
Measured over Baseline (Visit 2) and Final (Visit 3, Day 70). Through study completion (average of 2 years).
+1 more outcome measured

Conditions

Stress Response
Mental Stress
Multitasking Behavior and Multitasking Ability
Physiological Stress
Cognitive Symptoms
Motor Activity

Explore related trials

Healthy

Where it's being run

1 sites across 1 states
Florida1

Study leadership

  • Lewei Gu, PhD · PRINCIPAL_INVESTIGATOR · University of Florida

Who to contact

Maya E Waintraub, M.S.
[email protected]
847-246-2255
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

At least 110 pounds
Between 30 and 55 years
BMI between 18.9 and 29.9 kg/m²
A minimum education level of high school or above

Exclusion

Heavy caffeine users (consuming more than 300 mg/day or more than two cups of coffee per day)
Alcohol consumption exceeding three drinks per week
A smoking history of 10 years or more, or current use of cannabis products
Uncontrolled hypertension
Clinically diagnosed illnesses such as diabetes, cardiovascular disease, neurological disorders, or mental health conditions
Participants currently taking prescribed anti-inflammatory medications, antibiotics, or antidepressants that may affect study outcomes, particularly those related to blood and fecal sample analysis
Individuals who regularly take vitamin or mineral supplements and are unwilling to discontinue them for the duration of the study will not qualify.
Participants must be willing to maintain their current daily routine and lifestyle, undergo body weight and height measurements, and notify study coordinators of any illnesses or significant adverse life events during the study period
Those with specific dietary restrictions that prevent them from consuming the standardized breakfast sandwich required in the study protocol
Participants must successfully complete the on-site multitasking task as a screening measure prior to signing consent.
Beck's Depression Inventory score of 21 or higher
Beck's Anxiety Inventory score of 21 or higher
A history of severe suicidal tendencies, or seasonal depression
Pregnancy and breastfeeding (Female participants must complete four pregnancy tests throughout the study and track their menstrual cycle. Those unwilling to comply with these requirements will not be eligible.)
Potential participants must not have taken any anti-inflammatory medications, antibiotics, or antidepressants within the past three months prior to the start of the study
Individuals who were previously enrolled in IRB#202300950 will be excluded due to the learning effect of cognitive tests, ensuring accurate data collection for this study

What this trial measures

  • Cognitive task performance (serial subtraction accuracy)Baseline (Visit 2) and Final (Visit 3, Day 70). Through study completion (average of 2 years).

    Total number of correct subtractions during the multitasking cognitive task Measure Description: Counting backward aloud from a random number between 800-999 by 3, 7, and 17; performance scored as total correct subtractions across the task.

  • Cognitive task performance (serial subtraction errors)Baseline (Visit 2) and Final (Visit 3, Day 70). Through study completion (average of 2 years).

    Outcome Measure: Total number of incorrect subtractions during the multitasking cognitive task Measure Description: Same serial subtraction task; performance scored as total incorrect subtractions.