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Understanding Learning and Memory in Epilepsy

This study aims to understand how your brain learns and uses abstract ideas, like memories, to help you in new situations. Researchers are using special equipment, including the Cedrus RB-844 response pad, Adtech Behnke-Fried micro-electrodes, Neurolynx electrophysiology system, and Blackrock Cerestim stimulator, to record your brain activity and responses while you do simple tasks. The study is for adults aged 18 and older who have intractable epilepsy (epilepsy that doesn't respond to treatment) and are already undergoing invasive monitoring. To join, you need to have an IQ over 70 and be able to follow simple instructions. The main goals are to see how brain cells work together to learn abstract ideas, how these ideas help you adapt to new situations, and how electrical stimulation affects this process. The study plans to enroll 114 participants, but its current status is unclear.

Study design
This is an interventional study with an unclear status, planning to enroll 114 participants. It involves recording brain activity and responses while participants perform cognitive tasks.
What's involved
You will perform various cognitive tests on a computer during your hospital stay. This involves pressing buttons in response to questions.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoints, including neuronal activity and the effects of electrical stimulation, will be measured at 3 years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07454785

Neuronal Mechanisms of Learning and Utilizing Abstract Representations

Enrolling by Invitation
NAAges 18+InterventionalBasic science
Cedars-Sinai Medical Center
~114 participants
Updated 2026-06-03 on ClinicalTrials.gov
What's tested:Cedrus RB-844 response pad; Adtech Behnke-Fried micro-electrodes; Neurolynx electrophysiology system; Blackrock Cerestim stimulator

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Neuronal population activity
Measured over 3 years
+2 more outcomes measured

Conditions

Epilepsy Intractable

Explore related trials

Seizure Disorder

Where it's being run

1 sites across 1 states
California1

Study leadership

  • Ueli Rutishauser, PhD · PRINCIPAL_INVESTIGATOR · Cedars-Sinai Medical Center
  • Adam Mamelak, MD · PRINCIPAL_INVESTIGATOR · Cedars-Sinai Medical Center

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Intractable epilepsy, undergoing invasive monitoring
Age ≥18
Full Scale Intelligence Quotient \> 70
Ability to comprehend and perform simple behavioral tasks by pressing buttons on laptop computer in response to questions.

Exclusion

Determination by clinicians and investigators that a patient is unable to complete the behavioral tasks required for the protocol due to either cognitive limits, psychological limits, or pain.

What this trial measures

  • Neuronal population activity3 years

    Proportion of experiment sessions in which abstract representation emerged following successful learning of the task by the subject.

  • Facilitation of generalization3 years

    Strength of correlation between the presence of abstract representations at the neuronal level and the subjects ability to perform generalization.

  • Effect of electrical stimulation3 years

    Proportion of experiment sessions in which electrical stimulation to the hippocampus disrupted abstract representations.