Evaluating [18F]GATT-44 for Brain Imaging
This study is evaluating a new imaging agent called [18F]GATT-44. Researchers want to understand how it moves through the body, how it's processed, and how well it binds to specific targets in the brain. They will also check if the imaging results are consistent over time. This study is looking for healthy adults between 18 and 60 years old. Success will be measured by how consistently [18F]GATT-44 binds in the brain and by understanding its radiation dose. The current recruitment status is unclear.
- Study design
- This is an interventional study planning to enroll 32 healthy adult participants. It is not specified if it is randomized or blinded.
- What's involved
- You would undergo PET scans on two separate days to measure binding and reproducibility. Whole-body PET-CT images will also be taken on one of these days.
- Compensation
- Not stated in the trial record.
- Follow-up
- The primary endpoints are measured at PET Day 1 and PET Day 2, and for whole-body radiation dosimetry on PET Scan Day 1.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Evaluation of [18F]GATT-44 for Positron Emission Tomography Imaging of the GABA Transporter-1
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Richard E Carson, PhD · PRINCIPAL_INVESTIGATOR · Yale University
Who to contact
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What this trial measures
- Test-Retest reproducibility calculationsPET Day 1 and PET Day 2
Regional TACs are analyzed with kinetic models to generate regional volume of distribution (VT), using the metabolite-corrected arterial plasma concentrations over time as input function. Standardized uptake values (SUV) may also be generated.
- Specific binding levels of [18F]GATT44 in humans.PET Day 1 and PET Day 2
Binding potentials BPF, BPP, and BPND will be calculated from VT values, and reference models. White Matter will be the reference region to estimate nondisplaceable binding (VND).
- Whole body radiation dosimetry calculated from PET-CT imagesPET Scan Day 1
Radiation absorbed doses of each organ will be calculated.