Memory Enhancement in Aging With Optimal Dosing
This study is looking into ways to improve memory in healthy older adults using a non-drug approach called transcranial alternating current stimulation (tACS). This involves applying a low-intensity electrical current to the scalp to help brain networks that support memory. Researchers are testing different schedules of tACS, including 1-day, 3-day, and 5-day treatments, to find the best way to enhance memory. The goal is to develop drug-free options for memory decline often seen in aging and conditions like Alzheimer's disease. You might be able to join if you are 65 or older, have good vision, and do not have certain medical conditions like metal implants in your head or a history of neurological problems. The study will measure your visual working memory and how well you can stop interruptions at the start, one week, and one month after the treatment.
- Study design
- This is an interventional study planning to enroll 240 participants. It is testing different schedules of transcranial alternating current stimulation (tACS).
- What's involved
- You would have your memory and brain activity (EEG) measured at the start, one week after treatment, and one month after treatment. The study involves receiving tACS for 1, 3, or 5 days.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for one month after the intervention to measure memory and brain activity.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Memory Enhancement in Aging With Optimal Dosing
At a glance
Conditions
NCT07461584
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
111 Cummington Mall
Boston, Massachusettsstudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Robert Reinhart, PhD · PRINCIPAL_INVESTIGATOR · Boston University Charles River Campus
Who to contact
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Inclusion
Exclusion
What this trial measures
- Visual working memory capacity measured behaviorallyBaseline, 1-week after intervention, 1-month after intervention
Behavioral k-capacity estimate derived from the change-detection task
- Interruption suppression measured behaviorallyBaseline, 1-week after intervention, 1-month after intervention
Memory accuracy performance difference between interruption and control trials on the interruption working memory task
- EEG phase locking value (PLV) during working memory retentionBaseline, 1-week after intervention, 1-month after intervention
Phase locking value between frontotemporal EEG electrodes within the theta frequency band during the memory retention interval of the visual working memory task
- EEG phase amplitude coupling (PAC) during working memory retentionBaseline, 1-week after intervention, 1-month after intervention
Theta phase gamma amplitude cross-frequency coupling at temporal EEG electrodes during the memory retention interval of the visual working memory task