Study on EBUS Needle Cleaning for Lung Cancer Staging

This study is looking at how well different cleaning methods work for needles used during Endobronchial Ultrasound (EBUS) bronchoscopy. EBUS is a procedure where a doctor uses a special scope to look inside your airways and take samples from lymph nodes, often to check for lung cancer. The concern is that tiny cancer cells might stay on the needle after taking one sample and then contaminate the next sample, potentially leading to an incorrect diagnosis. This study will compare the usual cleaning method with an additional cleaning step called "purge cleaning" (flushing the needle into a separate vial). The goal is to see if this extra cleaning reduces contamination without affecting the ability to get a good diagnosis. You might be able to join if you are an adult aged 18 or older, are having an EBUS for suspected lung cancer, and will have samples taken from at least two lymph node areas.

Study design
This is an interventional study planning to enroll 204 participants. It will compare two different needle cleaning techniques.
What's involved
You would undergo a standard EBUS bronchoscopy procedure. The study will evaluate the cleaning techniques used during this procedure.
Compensation
Not stated in the trial record.
Follow-up
Your samples will be reviewed for contamination for up to 32 weeks after you join the study.

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NCT07461662

Evaluation of Endobronchial Ultrasound Needle Cleaning Techniques and Their Impact on Specimen Contamination

Not Yet Recruiting
NAAges 18+InterventionalDiagnostic
University of Mississippi Medical Center
~204 participants
Updated 2026-03-10 on ClinicalTrials.gov
What's tested:Purge cleaning

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Cytologic Contamination
Measured over From enrollment to the date of the pathological review report of the specimen taken during diagnostic EBUS sampling for a period of up to 32 weeks post enrollment and randomization in trial for each patient enrolled.
Lung Cancer (Locally Advanced or Metastatic)
1 sites across 1 states
Mississippi1
  • Yanglin Guo, MD · PRINCIPAL_INVESTIGATOR · University of Mississippi Medical Center

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Eligibility criteria

Inclusion

Adults aged 18 years or older
Patients undergoing standard-of-care EBUS bronchoscopy for evaluation of suspected lung malignancy
Patients undergoing sampling of 2 or more lymph node stations during EBUS bronchoscopy
Ability to provide informed consent

Exclusion

Age less than 18
Recent (1 month or less) radiation or procedural manipulation of lymph node stations that may significantly change lymph node architecture
  • Cytologic ContaminationFrom enrollment to the date of the pathological review report of the specimen taken during diagnostic EBUS sampling for a period of up to 32 weeks post enrollment and randomization in trial for each patient enrolled.

    To determine the presence of cytologic contamination following standard practice cleaning techniques