Inflammation in Primary and Secondary Malignancies of the Central Nervous System Using [C-11]-CS1P1

{ "Imaging Inflammation in Brain Cancers with [C-11]-CS1P1", "This study is looking at how a special imaging agent called [C-11]-CS1P1 (an S1P1 PET imaging agent) can help us understand inflammation in primary (starting in the brain) and secondary (spread to the brain) central nervous system cancers. Researchers want to see how this agent shows up in tumors compared to normal brain tissue. You might be able to join if you are an adult (18 or older) with a confirmed diagnosis of primary or secondary central nervous system cancer that hasn't been treated with radiation yet. The main goal is to measure how much of the [C-11]-CS1P1 agent is taken up by the tumor compared to healthy brain tissue. This study is currently recruiting 104 participants.", "design": "This is an interventional imaging study that will include 104 adult participants. It is a single-arm study, meaning all participants will receive the same intervention.", "commitments": "You would undergo a baseline [C-11]-CS1P1 PET scan and may have an optional Brain MRI. You will also be invited for a follow-up [C-11]-CS1P1 PET scan within 24 months of the first scan, ideally around 6 months after treatment.", "compensation": "Not stated in the trial record.", "follow_up": "Participants will have a follow-up scan within 24 months of their baseline scan, preferably within 6 months after treatment.", }

Study design
Not specified.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07462507

Inflammation in Primary and Secondary Malignancies of the Central Nervous System Using [C-11]-CS1P1

Recruiting
PHASE2Ages 18+InterventionalDiagnostic
Washington University School of Medicine
~104 participants
Updated 2026-04-21 on ClinicalTrials.gov
What's tested:[C-11]-CS1P1Brain MRI

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
[C-11]CS1P1 Standardized uptake value (SUV) ratio of tumor to non-tumor regions of interest (ROIs)
Measured over Baseline
Central Nervous System Cancer
Brain Metastases
1 sites across 1 states
Missouri1
  • Tammie L.S. Benzinger, M.D., Ph.D. · PRINCIPAL_INVESTIGATOR · Washington University School of Medicine
Tammie L.S. Benzinger, M.D., Ph.D.
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Eligibility criteria

Inclusion

Male or female, any race
Age ≥ 18 years
Capable of providing written informed consent OR having a legally authorized representative (LAR) to provide informed consent for volunteering to undergo research procedure
Has a clinical, radiographic, or pathological diagnosis of primary or secondary CNS malignancy that has not been treated with radiotherapy

Exclusion

Hypersensitivity to \[C-11\]-CS1P1 or any of its excipients
Contraindications to PET, CT or MRI (e.g. certain incompatible electronic medical devices, inability to lie still for extended periods) that make it potentially unsafe for the individual to participate
Prior cranial radiotherapy
Severe claustrophobia that would require general anesthesia
Women who are currently pregnant or breastfeeding
Any condition that, in the opinion of the Sponsor-Investigator or designee could increase risk to the participant, limit the participant's ability to tolerate the research procedures or interfere with the collection of the data (e.g., advanced renal or liver failure)
Current or recent (within 12 months prior to screening) participation in research studies involving radioactive agents such that the total research-related radiation dose to the participant in any given year would exceed the limits set forth in the U.S. Code of Federal Regulations (CFR) Title 21 Section 361.1. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?FR=361.1.
  • [C-11]CS1P1 Standardized uptake value (SUV) ratio of tumor to non-tumor regions of interest (ROIs)Baseline

    \[C-11\]CS1P1-SUV ratio at the baseline and associated 95% confidence interval (CI) will be calculated.