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Accelerated TMS for Post-Traumatic Stress Disorder

This study is testing a new brain stimulation treatment called accelerated transcranial magnetic stimulation (TMS) for adults with post-traumatic stress disorder (PTSD). PTSD can cause symptoms like flashbacks and avoidance after a traumatic event. Researchers will first use a special brain scan (fMRI) to create a personalized map of your brain connections. Then, they will use this map to guide the TMS treatment, which involves magnetic pulses to adjust brain activity. The study aims to see if this treatment is safe and helps reduce PTSD symptoms. They will enroll 15 adults, aged 18-65, who have been diagnosed with PTSD and have moderate to severe symptoms for at least three months. Success will be measured by changes in your PTSD symptoms using a questionnaire called the PCL-5.

Study design
This is an interventional study with an unclear phase, planning to enroll 15 participants. It is a pilot study evaluating the feasibility, safety, and preliminary effectiveness of the treatment.
What's involved
You would undergo a brain scan (fMRI) and then receive 50 sessions of TMS over 5 days, with 10 sessions per day. Your PTSD symptoms will be measured at the start, immediately after treatment, and then at 1 month and 3 months later.
Compensation
Not stated in the trial record.
Follow-up
Your PTSD symptoms will be checked at 1 month and 3 months after the treatment.

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NCT07463703

Accelerated Transcranial Magnetic Stimulation for Post-Traumatic Stress Disorder

Recruiting
NAAges 18–65InterventionalTreatment
Cognitive FX
~15 participants
Updated 2026-07-28 on ClinicalTrials.gov
What's tested:Accelerated functional-connectivity guided transcranial magnetic stimulation

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
PTSD Checklist for DSM-5 (PCL-5)
Measured over Baseline, post-treatment 5 days, 1 month, 3 months

Conditions

PTSD - Post Traumatic Stress Disorder

Explore related trials

Post-Traumatic Stress Disorder

Where it's being run

1 sites across 1 states
Utah1

Who to contact

Lynn Gaufin, MD
[email protected]
385-446-4158
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Exclusion

Cochlear implants
Deep brain stimulators
Vagus nerve stimulators
Aneurysm clips or coils
Stents in the neck or brain
Electrodes
Any implanted electronic devices 2. History of seizure disorder (excluding single childhood febrile seizure) 3. First-degree family member with epilepsy 4. History of significant head trauma with loss of consciousness \>10 minutes 5. History of stroke, brain tumor, or other neurological disorder 6. Neurosurgical procedures involving brain tissue

What this trial measures

  • PTSD Checklist for DSM-5 (PCL-5)Baseline, post-treatment 5 days, 1 month, 3 months

    A change in PTSD severity will be measured via administration of the PDSD Checklist for DSM-5 (PCL-5). This is a 20-question Likert scale, with scores ranging from 0 to 80. Higher scores indicate stronger PTSD symptoms.