Mobile Vehicle-Based Delivery of Lenacapavir for HIV Prevention

This study is looking at how well a mobile health van can deliver lenacapavir (LEN PrEP), a long-acting injectable medication for preventing HIV, to people experiencing housing instability in Los Angeles County. Many people who are unhoused face challenges getting HIV prevention care in traditional clinics. This study aims to see if providing LEN PrEP through mobile vans, which already offer other health services, can help overcome these barriers. The main goal is to measure how many people start using LEN PrEP after three months. You may be able to join if you are at least 18 years old, speak English or Spanish, have an unknown or negative HIV status, and are considered at risk for HIV by a clinician. The study is currently unclear on its recruitment status, but plans to enroll 100 participants.

Study design
This is an observational study, meaning researchers will watch and record information without assigning specific treatments. It plans to enroll 100 participants.
What's involved
You would need to be reached by a UCLA HHC mobile van, provide informed consent, and be willing and able to follow study procedures. The study will assess your HIV status on the day of enrollment.
Compensation
Not stated in the trial record.
Follow-up
The study will measure the uptake of LEN PrEP at 3 months after you enroll.

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NCT07467018

Mobile Vehicle-Based Delivery of Lenacapavir Pre-Exposure Prophylaxis in Los Angeles County

Recruiting
Not specifiedAges 18+Observational
University of California, Los Angeles
~100 participants
Updated 2026-04-23 on ClinicalTrials.gov
What's tested:Community-based healthcare deliveryLenacapavir

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Uptake of LEN PrEP
Measured over 3 months after enrollment
HIV Prevention
1 sites across 1 states
California1

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Eligibility criteria

Inclusion

Being reached for mobile health services by a UCLA HHC mobile van
≥18 years of age
Able to provide informed consent
English or Spanish-speaking
Willing and able to comply with study procedures
HIV unknown or negative status and HIV negative based on rapid 4th generation Ag/Ab test on the day of enrollment
At-risk for HIV, based on clinician assessment (based on CDC guidelines; includes any individual requesting PrEP, regardless of reported risk factors for HIV)
Pregnant and breastfeeding women/people can be offered LEN with counseling about benefits and risks.

Exclusion

Any clinical or psychosocial condition or prior therapy that, in the opinion of the investigator, would make the participant unsuitable for the study or unable to take LEN PrEP
Known hypersensitivity to the study drug, the metabolites, or formulation excipient
BMI \<35 kg/m2 (77 pounds)
On oral or other long-acting PrEP and unwilling to discontinue
Already taking LEN for HIV prevention
Known HIV diagnosis or positive 4th generation HIV Ab/Ag test (on day of enrollment) or subsequent lab-based confirmatory testing.
  • Uptake of LEN PrEP3 months after enrollment

    The primary outcome will be defined as receiving a first injection of LEN (along with both oral doses on days 1 and 2).