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NCT07467473

Causal Role of Rostromedial Prefrontal Cortex for Positive Savoring in Depression

Enrolling by Invitation
NAAges 18–65InterventionalBasic science
Florida State University
~48 participants
Updated 2026-05-20 on ClinicalTrials.gov
What's tested:Accelerated Intermittent Theta Burst Transcranial Magnetic Stimulation

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Late Positive Potential during Positive Savoring
Measured over From baseline EEG to post-stimulation EEG approximately 2 weeks apart

Conditions

Left Rostromedial Prefrontal Cortex - Accelerated Intermittent Theta Burst
Left Dorsolateral Prefrontal Cortex - Accelerated Intermittent Theta Burst
Left Primary Somatosensory Cortex - Accelerated Intermittent Theta Burst

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Where it's being run

1 sites across 1 states
Florida1

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

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Eligibility criteria

Inclusion

Between the ages of 18 and 65
Able to provide informed consent
Have normal or corrected vision
Right handed
Willing to comply with all study procedures and be available for the duration of the study
Speak and understand English
Not color blind
Acceptable suicide risk as determined by less than 5 on the Depression Symptom Index Suicidality Subscale (DSI-SS)
A diagnosis of major depressive disorder (current episode) on the Structured Clinical Interview for the DSM-5 (SCID-5)
Between the ages of 18 and 65

Exclusion

ADHD (currently under treatment)
Neurological disorders and conditions. Including but not limited to: history of epilepsy, seizures (except childhood febrile seizures), dementia, history of stroke, Parkindon's disease, multiple sclerosis, cerebral aneurysm, brain tumors
Medical or neurological illness or treatment for a medical disorder that could interfere with study participation. For example, unstable cardiac disease, HIV/AIDS, malignancy, liver or renal impairment
Prior brain surgery
Any brain devices/implants, including cochlear implants and aneurysm clips, cardiac pacemaker, or any other implanted electronic device
History of current traumatic brain injury
Pregnancy (for females)
Claustrophobia
DSM-5 diagnosis of present moderate or severe substance use disorder or alcohol use disorder, and past severe substance use disorder or alcohol use disorder, bipolar disorder, or psychotic disorder
Anything that in the opinion of the investigator would place the participant at increased risk or preclude the participant's full compliance with or completion of the study

What this trial measures

  • Late Positive Potential during Positive SavoringFrom baseline EEG to post-stimulation EEG approximately 2 weeks apart

    The late positive potential (LPP) is an established event-related potential that has been shown to be higher when savoring positive feelings elicited by positive images compared to neutral images. Changes in the LPP will be assessed from baseline EEG to post-stimulation EEG and compared between stimulation sites (left rostromedial PFC, left dorsolateral PFC, left primary somatosensory cortex).