Exercise and Breast Milk Composition Study

This study is looking at how exercise and physical activity during and after pregnancy might change breast milk. Researchers want to see if these changes in breast milk, specifically in its fats (lipidome) and other small molecules (metabolome), could affect how babies use energy and potentially help prevent childhood obesity. You might be able to join if you are a woman between 18 and 45 years old, have a healthy pregnancy, and plan to exclusively breastfeed for at least three months. The study aims to enroll 200 participants and is actively recruiting. By understanding this process, the study hopes to improve advice for exercise during and after pregnancy to benefit infant health.

Study design
This interventional study plans to enroll 200 women. Participants randomized to the Active group will have weekly phone calls to review and increase exercise goals.
What's involved
Participants in the Active group will have weekly phone calls with study staff. Breast milk will be collected and analyzed at 8 weeks.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoints for breast milk analysis are measured at 8 weeks.

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NCT07467694

Postnatal Exercise to Activate Baby's Brown Fat

Recruiting
NAAges 18–45InterventionalPrevention
Joslin Diabetes Center
~200 participants
Updated 2026-03-12 on ClinicalTrials.gov
What's tested:Active group

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Altered breast milk lipidome
Measured over 8 weeks
+1 more outcome measured
Childhood Obesity Prevention
Childhood Obesity
Physical Activity
Lactation
Breastfeeding
Pregnancy
Exercise
2 sites across 2 states
Massachusetts1
Oklahoma1

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Eligibility criteria

Inclusion

18-45 y of age at the time of enrollment
Pre-gravid or first trimester BMI 18.5 -40 kg/m2
Uncomplicated singleton pregnancy
Intention to exclusively breastfeed for \>3 months and, if parity \>1, that they successfully breastfed a previous pregnancy
Term pregnancy (gestational age 37 to \<42 weeks)
Infant with birth weight \>10th percentile of weight for gestational age

Exclusion

Any obstetric contra-indication to exercise at 1 month
Diagnosis of uncontrolled (HbA1c \>7%) type 1 or type 2 diabetes, or gestational diabetes managed with insulin
Intrauterine growth restriction
Pre-eclampsia or other pregnancy complications
Alcohol, cannabis or tobacco use
Known congenital metabolic, endocrine disease, or congenital illness affecting infant feeding/growth
Major fetal anomalies
Musculoskeletal issues that would make exercise difficult
  • Altered breast milk lipidome8 weeks

    Milk composition measured through lipidomics

  • Altered breast milk metabolome8 weeks

    Human milk composition measured via metabolomics