Transcranial Direct Current Stimulation (tDCS) for Schizophrenia and Schizoaffective Disorder
This study is exploring if a non-invasive brain stimulation technique called transcranial direct current stimulation (tDCS) can help improve how people with schizophrenia or schizoaffective disorder recognize emotions from faces. tDCS involves applying a very low electrical current to the scalp over a specific brain area (MT+) that processes motion. Researchers believe that difficulties in seeing motion contribute to problems with recognizing emotions, which can affect social interactions. The study will compare tDCS to a sham (inactive) stimulation. Success will be measured by changes in brain activity (detected using fMRI and ERP) in the MT+ area and improvements in emotion recognition and understanding social cues. The study aims to enroll 120 participants with schizophrenia or schizoaffective disorder, aged 18-55, who are not severely ill and have an IQ above 70. The current recruitment status is unclear.
- Study design
- This is an interventional study with a randomized, parallel group design, comparing active tDCS to sham stimulation. It plans to enroll 120 participants with schizophrenia or schizoaffective disorder.
- What's involved
- Participants will undergo baseline assessments and physiological evaluations. They will receive either active or sham tDCS, with brain activity measured during these sessions on study days 3 and 10.
- Compensation
- Not stated in the trial record.
- Follow-up
- Brain activity will be measured during the intervention on study days 3 and 10. The record does not specify follow-up beyond this.
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Non-invasive Brain Stimulation Using Tdcs of the Third (of Many) Visual Pathways
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Daniel C Javitt, MD, PhD · PRINCIPAL_INVESTIGATOR · Nathan Kline Institute
- Antigona Martinez, PhD · PRINCIPAL_INVESTIGATOR · Nathan Kline Institute
Who to contact
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What this trial measures
- MT+ activation as determined using fMRISimultaneously with the administration of the active or sham tDCS intervention during study day 10
Magnitude of activation in area MT+ during random dot kinematogram (RDK) stimulation measured by the beta weight of the BOLD fMRI signal, expressed in units of percentage signal change
- MT+ activation as determined using event-related potentials (ERP)Simultaneously with the administration of the active or sham tDCS intervention during study day 3
Amplitude of the ERP response to random dot kinematogram (RDK) stimulation, measured in microvolts