Transcranial Direct Current Stimulation (tDCS) for Schizophrenia and Schizoaffective Disorder

This study is exploring if a non-invasive brain stimulation technique called transcranial direct current stimulation (tDCS) can help improve how people with schizophrenia or schizoaffective disorder recognize emotions from faces. tDCS involves applying a very low electrical current to the scalp over a specific brain area (MT+) that processes motion. Researchers believe that difficulties in seeing motion contribute to problems with recognizing emotions, which can affect social interactions. The study will compare tDCS to a sham (inactive) stimulation. Success will be measured by changes in brain activity (detected using fMRI and ERP) in the MT+ area and improvements in emotion recognition and understanding social cues. The study aims to enroll 120 participants with schizophrenia or schizoaffective disorder, aged 18-55, who are not severely ill and have an IQ above 70. The current recruitment status is unclear.

Study design
This is an interventional study with a randomized, parallel group design, comparing active tDCS to sham stimulation. It plans to enroll 120 participants with schizophrenia or schizoaffective disorder.
What's involved
Participants will undergo baseline assessments and physiological evaluations. They will receive either active or sham tDCS, with brain activity measured during these sessions on study days 3 and 10.
Compensation
Not stated in the trial record.
Follow-up
Brain activity will be measured during the intervention on study days 3 and 10. The record does not specify follow-up beyond this.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07469384

Non-invasive Brain Stimulation Using Tdcs of the Third (of Many) Visual Pathways

Recruiting
NAAges 18–55InterventionalTreatment
Nathan Kline Institute for Psychiatric Research
~120 participants
Updated 2026-03-13 on ClinicalTrials.gov
What's tested:transcranial direct current stimulationSham stimulation

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
MT+ activation as determined using fMRI
Measured over Simultaneously with the administration of the active or sham tDCS intervention during study day 10
+1 more outcome measured
SCHIZOPHRENIA 1 (Disorder)
Schizo Affective Disorder
1 sites across 1 states
New York1
  • Daniel C Javitt, MD, PhD · PRINCIPAL_INVESTIGATOR · Nathan Kline Institute
  • Antigona Martinez, PhD · PRINCIPAL_INVESTIGATOR · Nathan Kline Institute

Opens a ready-to-send draft in your own email app — review before sending.

  • MT+ activation as determined using fMRISimultaneously with the administration of the active or sham tDCS intervention during study day 10

    Magnitude of activation in area MT+ during random dot kinematogram (RDK) stimulation measured by the beta weight of the BOLD fMRI signal, expressed in units of percentage signal change

  • MT+ activation as determined using event-related potentials (ERP)Simultaneously with the administration of the active or sham tDCS intervention during study day 3

    Amplitude of the ERP response to random dot kinematogram (RDK) stimulation, measured in microvolts