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Hysteroscopy for Pregnancy of Unknown Location

This study is looking at a procedure called hysteroscopy (using a thin, lighted tube to look inside the uterus) for women who have a pregnancy of unknown location (PUL). A PUL means that an early pregnancy can't be seen on an ultrasound. In this study, all participants will have a hysteroscopy before a D&C (dilation and curettage, a procedure to remove tissue from the uterus). The main goal is to see if abnormal tissue is present in the uterus within one week after the procedure. You might be able to join if you are 18 or older, have a positive pregnancy test, and your hCG (pregnancy hormone) levels are not rising normally. This study aims to find better ways to diagnose and treat PUL, especially since current methods can sometimes delay treatment for ectopic pregnancies.

Study design
This is an interventional study with an estimated enrollment of 60 women. All participants will receive the hysteroscopy intervention.
What's involved
You will undergo a diagnostic hysteroscopy followed by a dilation and curettage. The primary outcome is measured within one week after the procedure.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome is measured from enrollment to one week post-operatively.

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NCT07469605

Hysteroscopy for the Diagnosis and Treatment of Pregnancy of Unknown Location

Recruiting
NAAges 18+InterventionalDiagnostic
University of Pennsylvania
~60 participants
Updated 2026-03-13 on ClinicalTrials.gov
What's tested:Hysteroscopy for diagnosis and treatment of pregnancy of unknown location

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Presence or absence of abnormal tissue within the endometrial cavity
Measured over From enrollment to 1 week post-operatively

Conditions

Pregnancy of Unknown Location

Explore related trials

Ectopic PregnancyPregnancy of unknown locationSpontaneous Abortion

Where it's being run

1 sites across 1 states
Pennsylvania1

Who to contact

Margaret A Rush, MD
[email protected]
267-624-4249
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Eligibility criteria

Inclusion

Patients 18 years of age and older
Patients undergoing care with (1) positive serum hcg and (2) abnormal hcg trend, as defined by \<50% rise in bHCG over 48h period, repeated across three lab values.
Patients with pregnancy via unassisted conception, conception after ovulation induction and/or intrauterine insemination, and/or embryo transfer
Well established pregnancy dating, either with known LMP, or dating by IUI or embryo transfer

Exclusion

Patients with known abnormal cavity (history of fibroids, septum, or uterine anomaly)
Patients who are hemodynamically unstable or with an acute abdomen

What this trial measures

  • Presence or absence of abnormal tissue within the endometrial cavityFrom enrollment to 1 week post-operatively

    Intra-operative photographs will be taken of the participants uterine cavities at five standardized locations (left cornua, right cornua, anterior uterine wall, posterior uterine wall, and entire uterine cavity at level of internal os). The presence or absence of abnormal tissue will be documented, and findings qualitatively compared between the cavities of participants with the final diagnosis of non-viable intrauterine pregnancy and an ectopic pregnancy.