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Study on Environmental Temperatures and Breathing Control

This study is looking at how different environmental temperatures (cold, hot, or comfortable) affect your breathing and thinking abilities, especially when your breathing feels harder. Researchers want to understand if combining hard breathing with temperature stress makes it even more difficult. You might be able to join if you are between 18 and 40 years old, speak English, exercise regularly, and have normal lung function. The study will measure how your thinking speed and accuracy change, as well as your perception of breathing difficulty, after experiencing different temperatures. The study is currently unclear on its recruitment status and plans to enroll 15 participants.

Study design
This interventional study plans to enroll 15 participants. It will compare your responses in three different temperature environments: thermoneutral, cold, and hot.
What's involved
You will participate in three separate sessions, each lasting about 90 minutes. During these sessions, you'll wear a special suit that controls your body temperature while resting in a controlled chamber, and you'll complete breathing tasks and cognitive tests.
Compensation
Not stated in the trial record.
Follow-up
Your performance and perception will be measured before and after each breathing task on Days 1, 2, and 3.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07470086

The Role of Environmental Temperatures in Respiratory Control

Not Yet Recruiting
NAAges 18–40InterventionalBasic science
Indiana University
~15 participants
Updated 2026-03-13 on ClinicalTrials.gov
What's tested:Thermoneutral temperature environmentCold temperature environmentHot temperature environment

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Stroop Color-Word Test Time Performance
Measured over Before and after each breathing task on Days 1, 2, 3 (each approximately 90 minutes in duration)
+3 more outcomes measured

Conditions

Work of Breathing

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Healthy Volunteers

NCT07470086

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Multidisciplinary Engineering and Sciences Hall (MESH)

    Bloomington, Indianastudy coordinator listed

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Who to contact

Timothy D Mickleborough, PhD
[email protected]
812-855-0753
Email the study team

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Eligibility criteria

Inclusion

Between the ages of 18-40 years old.
English speaking and reading.
Self-reported weekly activity of at least 120 minutes/week of high intensity exercise for the previous 2 years.
Normal pulmonary function assessed by a resting forced expiratory volume in 1 second over forced vital capacity (FEV1/FVC) \> 75% of predicted.
Normal cognitive function assessed using the Montreal cognitive function test \[18\].
Body mass index (BMI) ≤ 35 kg/m2.
Females with a regular menstrual cycle that ranges from 21-35 days (eumenorrhea)

Exclusion

History of smoking or recreational smoking, cardiovascular disease, renal disease, pulmonary disease (including asthma or exercise-induced asthma), neurological disease, and metabolic disease.
Are pregnant or could possibly be pregnant by self-report.
Are color blind.
Known allergy or hypersensitivity latex.
Take selective serotonin reuptake inhibitors, stimulant medication, antibiotics, and chronically consume pain medication (Aleve, Tylenol, etc.).
Resting blood pressure of \> 130mmHg systolic or 90 mmHg diastolic and/or resting pulse rate of \> 100 bpm.
Females with irregular menstrual cycles (oligomenorrhea) that ranges from 36-90 days, and females with the absence of a menstrual cycle (amenorrhea).
Taking birth control for the sole purpose of period cessation (eg., Mirena IUD)

What this trial measures

  • Change in Stroop Color-Word Test Time PerformanceBefore and after each breathing task on Days 1, 2, 3 (each approximately 90 minutes in duration)

    Time performance on the Stroop Color-Word Test (min:sec) will be measured every 45 minutes during each experimental breathing task.

  • Change in Stroop Color-Word Test Error PerformanceBefore and after each breathing task on Days 1, 2, 3 (each approximately 90 minutes in duration)

    The number of errors on the Stroop Color-Word Test will be measured every 45 minutes each experimental breathing task.

  • Change in Perception of Dyspnea IntensityBefore and after each breathing task on Days 1, 2, 3 (each approximately 90 minutes in duration)

    Participants will rate perception of dyspnea (breathing) intensity on a visual analog scale (VAS) every 45 minutes during each breathing task. The participant will draw a vertical marker line on a horizontal line (100mm), indicating their breathing perception from "not noticeable" (0mm) to "maximal imaginable intensity" (100mm).

  • Change in Perception of Dyspnea UnpleasantnessBefore and after each breathing task on Days 1, 2, 3 (each approximately 90 minutes in duration)

    Participants will rate perception of dyspnea (breathing) unpleasantness on a visual analog scale (VAS) every 45 minutes during each breathing task. The participant will draw a vertical marker line on a horizontal line(100mm), indicating their breathing perception from "not unpleasant"(0mm) to "maximal imaginable unpleasantness" (100mm).