Transcutaneous Vagus Nerve Stimulation (tVNS) and Stress Regulation

This study is looking at how people handle stress during performance tasks and if a non-invasive ear device called Transcutaneous Vagus Nerve Stimulation (tVNS) can help. You would be randomly assigned to receive either active tVNS or a sham (inactive) version. You'd also be assigned to either prepare a speech under stressful conditions or complete a non-stressful writing task. Researchers will measure your self-reported stress levels before and after the task to see if tVNS makes a difference. The study aims to enroll 200 adults between 18 and 65 years old who are fluent in English and have no history of neurological or psychiatric disorders, cardiovascular disease, or implanted electrical devices. The current status of the study is unclear.

Study design
This is a randomized, double-blind interventional study with 200 planned participants. You would be randomly assigned to one of four groups: active tVNS with a stress task, active tVNS with a control task, sham tVNS with a stress task, or sham tVNS with a control task.
What's involved
You would participate in a single laboratory session where you wear a tVNS device and a heart rate monitor. You would also complete short questionnaires about your feelings before and after a task.
Compensation
Not stated in the trial record.
Follow-up
Your self-reported stress will be measured at baseline (pre-task) and immediately post-task during a single laboratory session.

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NCT07470229

Transcutaneous Vagus Nerve Stimulation (tVNS) and Stress Regulation During Performance Tasks

Not Yet Recruiting
NAAges 18–65InterventionalBasic science
University of Florida
~200 participants
Updated 2026-03-13 on ClinicalTrials.gov
What's tested:Transcutaneous Vagus Nerve Stimulation (tVNS)Evaluative Stress Task

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Self-Reported Stress
Measured over Baseline (pre-task) and immediately post-task during a single laboratory session.
Stress Response
1 sites across 1 states
Florida1
  • Trevor Foulk, Organizational Behavior · STUDY_DIRECTOR · University of Florida
  • Dustin Hegland, MD-ANESTHESIOLOGY-GENERAL · STUDY_DIRECTOR · University of Florida
Pedepo Emmanuel, Organizational Behavior
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  • Self-Reported StressBaseline (pre-task) and immediately post-task during a single laboratory session.

    Self-reported stress assessed using a questionnaire/scale administered before and after the performance task to capture changes in perceived stress during the laboratory session.