Family Building Decision Support for Female Adolescent and Young Adult Cancer Survivors

This study is testing a program called "Nurse Navigator-Delivered Family Building Decision Support" to help young women who have had cancer make informed decisions about starting a family. Many young women who have had cancer face challenges with fertility, concerns about pregnancy, and emotional stress when planning for parenthood. This program involves four video calls over 4-6 weeks, providing personalized information about reproductive health based on your cancer type and treatments (like chemotherapy or radiation). The goal is to see if this program is practical and helpful for participants. You may be able to join if you are a female cancer survivor between 18 and 39 years old, were diagnosed with cancer between ages 15-39, have finished your cancer treatment, and received treatments that could affect fertility or pregnancy.

Study design
This is an interventional study, meaning participants will receive a specific program. It plans to enroll 48 female adolescent and young adult cancer survivors.
What's involved
You would participate in four weekly or biweekly videoconference sessions, each lasting about 60 minutes, over 4-6 weeks. You will also receive an NCI booklet about life after cancer treatment.
Compensation
Not stated in the trial record.
Follow-up
Your progress will be checked after treatment (4-6 weeks) and again at follow-up (8-10 weeks).

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NCT07471685

Family Building Decision Support for Female Adolescent and Young Adult Cancer Survivors

Recruiting
NAAges 18–39InterventionalSupportive care
Duke University
~48 participants
Updated 2026-05-14 on ClinicalTrials.gov
What's tested:Nurse Navigator-Delivered Family Building Decision SupportSurvivorship Education

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Feasibility as measured by number of adolescents and young adults (AYAs) enrolled
Measured over up to 10 months
+6 more outcomes measured
Cancer Survivorship
Family Planning
Adolescent and Young Adult Cancer
1 sites across 1 states
North Carolina1
  • Caroline S Dorfman, PhD · PRINCIPAL_INVESTIGATOR · Duke University

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Eligibility criteria

Inclusion

Female (biological sex) AYA cancer survivor age 15-39 at original diagnosis and 18-39 at enrollment.
Completed cancer treatment with curative intent.
Prior exposure to treatments posing gonadotoxic risk (e.g., alkylating agents, total body irradiation) and/or treatments increasing obstetric risk (e.g., chest radiation, radiation to uterus, anthracycline exposure).
Has not completed family building.
Able to speak/read English.
Willing and able to complete videoconference sessions and REDCap surveys.

Exclusion

Visual, hearing, or cognitive impairment or severe mental illness that would interfere with participation as determined by study staff.
  • Feasibility as measured by number of adolescents and young adults (AYAs) enrolledup to 10 months

    Feasibility will be assessed by study enrollment. The intervention will be considered feasible if N=48 AYAs enroll during the 10-month study period.

  • Feasibility as measured by the number of participants who complete all four sessionsPost-treatment (4-6 weeks)

    The intervention will be considered feasible if \>80% of participants complete all four sessions.

  • Feasibility as measured by frequency of program skills usePost-treatment (4-6 weeks), follow-up (8-10 weeks)

    Feasibility will be assessed by a novel questionnaire designed to assess use of program skills (intervention strategies). Participants will be asked to evaluate the frequency with which they used skills or ideas presented in the intervention program, on a scale from 1 (not at all) to 6 (every day), since their last study session.

  • Feasibility as measured by frequency of specific program skills usePost-treatment (4-6 weeks), follow-up (8-10 weeks)

    Feasibility will be assessed by a novel questionnaire designed to assess use of program skills (intervention strategies). Participants will be asked to evaluate use of 16 specific program skills or strategies since their last study session, on a scale of 1 (not at all) to 5 (6 or more days per week).

  • Acceptability as measured by the Client Satisfaction QuestionnairePost-treatment (4-6 weeks)

    The Client Satisfaction Questionnaire is an 8-item scale assessing participants' views of an intervention as acceptable and satisfactory. Items are rated on a 4-point scale (e.g., 1 "very dissatisfied" to 4 "very satisfied") and averaged. The intervention will be considered acceptable if \>80% of intervention arm participants rate it as \>3 out of 4.

  • Acceptability as measured by the Treatment Acceptability QuestionnairePost-treatment (4-6 weeks)

    The Treatment Acceptability Questionnaire is a six-item scale assessing participants' views of an intervention as acceptable, ethical, and effective. Items are rated on a 7-point Likert scale (e.g., 1 "very unacceptable" to 7 "very acceptable") and averaged. The intervention will be acceptable if \>80% of intervention arm participants rate it as \>5 out of 7 on the TAQ.

  • Acceptability as measured by the Satisfaction with Therapy and Therapist Scale-Revised (STTS-R)Post-treatment (4-6 weeks)

    Participants will complete the 13-item Satisfaction with Therapy and Therapist Scale-Revised specific to the program they received. The first 12 items ask participants to rate their agreement with statements related to intervention satisfaction on a 5-point scale ranging from "strongly disagree" (1) to "strongly agree" (5). The 13th item asks "How much did the intervention help with your symptoms?" with 5 answer choices ranging from "made things a lot better" to "made things a lot worse."