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Creatine Supplementation and Kidney Health During Exercise in the Heat

This study is looking into whether taking creatine monohydrate for one week affects inflammation, markers of acute kidney injury (AKI) risk, and thinking skills in active, healthy young adults. Participants will either receive creatine monohydrate or a placebo (maltodextrin) for 8 days. Researchers will measure a specific urine biomarker (IGFBP7 x TIMP-2; NephroCheck®) to see if creatine changes the risk of AKI after exercising in the heat. The study is currently unclear on its recruitment status and plans to enroll 20 participants between 18 and 45 years old who are physically active and have good aerobic fitness.

Study design
This interventional study plans to enroll 20 participants. It is a placebo-controlled study, meaning some participants will receive creatine monohydrate and others will receive a placebo.
What's involved
You would have three visits to the lab: one for baseline measurements and two for experimental trials. These visits will involve paperwork, cognitive tests, body measurements, and a maximal exercise test on a cycle.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint measures changes in a urine biomarker from immediately before exercise to 1 hour after exercise in the heat.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07472426

Effects of Creatine Supplementation on Cognitive Measures and Markers of Acute Kidney Injury After Exercise in the Heat

Recruiting
NAAges 18–45InterventionalBasic science
University of Northern Iowa
~20 participants
Updated 2026-03-16 on ClinicalTrials.gov
What's tested:Creatine MonohydrateMaltodextrin (Placebo)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Urine Biomarker of Acute Kidney Injury Risk from Creatine Use Prior to Exercise in the Heat (The mathematical product of IGBFP7 and TIMP-2 [IGFBP7 x TIMP-2; NephroCheck®])
Measured over Change in urinary IGBP7 x TIMP-2 from immediately before exercise in the heat to 1 hour after exercise in the heat.

Conditions

Acute Kidney Injury
Exertional Heat Illness

Explore related trials

Healthy

Where it's being run

1 sites across 1 states
Iowa1

Who to contact

Assistant Professor, PhD
[email protected]
5635137807
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Age range: 18-45 years old
Physical Activity Level: Classified as 'active' using the criteria of engaging in planned exercise at least 3x/week, for a minimum of 30 minutes per session, over the past 3 months
Aerobic Fitness Level: Subjects must have an aerobic fitness classification of at least 'good' per American College of Sports Medicine (ACSM) criteria and assessed via maximal oxygen uptake test
Health Status: Free of any known cardiovascular, metabolic, renal, or neurologic conditions.
Physical Limitations: Indicates no physical limitations to cycling for \~ 90 minutes
Supplementation: Reports no use of creatine within the past 4 weeks
Recent Illness: Reports no presence of illness, vomiting, or diarrhea in the previous three days.

Exclusion

Known allergy to creatine or maltodextrin.
History of adverse heat-related events (e.g., heat exhaustion, heat stroke, severe dehydration requiring medical intervention)
Reports use of medications or supplements that may interfere with thermoregulation, heart rate, kidney injury or blood pressure responses during exercise (e.g. NSAID)

What this trial measures

  • Change in Urine Biomarker of Acute Kidney Injury Risk from Creatine Use Prior to Exercise in the Heat (The mathematical product of IGBFP7 and TIMP-2 [IGFBP7 x TIMP-2; NephroCheck®])Change in urinary IGBP7 x TIMP-2 from immediately before exercise in the heat to 1 hour after exercise in the heat.

    Concentrations of both IGBFP7 and TIMP-2 will be measured in the urine. The mathematical product of these values (IGFBP7 x TIMP-2) will then be calculated and reported for each time point.