Veverimer for Osteopenia and Bone Health

This study is looking into whether a medication called veverimer can help adults with osteopenia (weaker bones). Veverimer is a powder you mix with water. The goal is to see if veverimer can reduce the amount of acid your body gets rid of in your urine, which might then lead to less bone breakdown. We want to understand how well different doses of veverimer work compared to a placebo (an inactive substance), and to check its safety. We will also look at how veverimer affects bone formation and physical performance. You might be able to join if you are 50 or older and have osteopenia. The study is currently recruiting about 60 participants.

Study design
This is an interventional study comparing veverimer taken daily or every other day, to a placebo. Approximately 60 participants will be enrolled.
What's involved
You would take veverimer or placebo for 8 weeks and visit the clinic 8 times for checkups and tests. You would also keep a medication diary.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint is measured at screening, week 2, week 8, and week 8 +1 day.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07473713

Veverimer to Decrease Net Acid Excretion and Bone Resorption in Adults With Osteopenia

Recruiting
PHASE1Ages 50+InterventionalPrevention
Tufts Medical Center
~60 participants
Updated 2026-04-06 on ClinicalTrials.gov
What's tested:veverimer dailyveverimer every other dayPlacebo

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
24-hr urinary net acid excretion
Measured over measured at screening, week 2, week 8 and week 8 +1day
Osteopenia
1 sites across 1 states
Massachusetts1

Opens a ready-to-send draft in your own email app — review before sending.

  • 24-hr urinary net acid excretionmeasured at screening, week 2, week 8 and week 8 +1day