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EMS-Initiated Buprenorphine for Opioid Use Disorder

This study is looking at how well paramedics (EMS) can start treatment with buprenorphine for people with opioid use disorder. Buprenorphine is a medication used to treat opioid addiction. The study wants to see if starting buprenorphine treatment in an emergency setting is practical, safe, and helps people get into ongoing treatment. You can join if you are 18 or older and are offered or receive buprenorphine treatment from EMS, or if you decline it. The study will measure how many people get into treatment within 10 days after their EMS encounter. The current recruitment status is unclear, but the study plans to enroll 495 people.

Study design
This is an observational study, meaning researchers will watch and collect information without giving specific treatments. It will involve about 495 participants and will first do smaller studies to refine the process before a larger study.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The study will measure outcomes within 10 days after the EMS encounter and also within 30 days for the later part of the study.

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NCT07475728

EMS-Initiated Buprenorphine

Recruiting
Not specifiedAll AgesObservational
Yale University
~495 participants
Updated 2026-08-27 on ClinicalTrials.gov

At a glance

Recruiting sites
3 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Primary Outcome Measure for Pragmatic Field Study
Measured over Baseline
+1 more outcome measured

Conditions

Opioid Use Disorder

Explore related trials

Opioid Use Disorder

Where it's being run

3 sites across 3 states
California1
Minnesota1
New Jersey1

Study leadership

  • Gail D'Onofrio, MD, MS · PRINCIPAL_INVESTIGATOR · Yale University

Who to contact

Gail D'Onofrio, MD, MS
[email protected]
12037857059
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Eligibility criteria

Inclusion

18 years of age or older
Treated by the EMS-Initiated buprenorphine clinical protocol which includes:
Willing to follow study procedures.
Able to speak English sufficiently to understand study procedures, and to provide verbal and electronic/written consent.

Exclusion

Patients who lack decision making capacity
Patients who are in police or protective custody

What this trial measures

  • Primary Outcome Measure for Pragmatic Field StudyBaseline

    Feasibility and acceptability will be measured by the proportion of patients who accept EMS-initiated BUP among all patients who are offered the EMS-initiated BUP clinical protocol.

  • Primary Outcome Measure for the Single Arm Prospective TrialWithin 10 days after EMS encounter

    The proportion of participants engaged in MOUD within 10 days post EMS-initiated BUP among participants who received BUP and consented to be followed