Exercise and Protein Efficiency in Type 2 Diabetes

This study is looking at how a 12-week exercise program affects how your body uses protein if you have Type 2 Diabetes (T2D). Researchers will compare 15 older adults (65 years or older) with T2D to 15 older adults without T2D. The exercise program involves moderate-to-vigorous aerobic and strength training 2-3 times a week. The main goal is to understand how exercise changes protein efficiency in people with T2D. To join, you must be at least 65 years old, have a BMI between 25-40, and not have done structured exercise in the past 6 months. If you have T2D, you need a physician diagnosis with an HbA1c (a measure of blood sugar over time) greater than 6. The current recruitment status is unclear.

Study design
This is a randomized controlled trial involving 30 participants, split into two groups: 15 with Type 2 Diabetes and 15 without. Participants will undergo a 12-week exercise program.
What's involved
You would participate in a 12-week progressive exercise training program 2-3 times per week. This includes pre- and post-testing with body composition measures, glucose tolerance tests, fitness tests, and dietary protein efficiency assessments involving drinks, urine, and breath samples.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint is measured from enrollment to the end of the 12-week intervention, so follow-up is for 12 weeks.

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NCT07477067

Exercise and Protein Efficiency in T2D

Recruiting
NAAges 65+Interventional
University of Illinois at Urbana-Champaign
~30 participants
Updated 2026-04-29 on ClinicalTrials.gov
What's tested:12 week progressive exercise training

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Define how exercise modifies protein efficiency in T2D
Measured over From enrollment to end of 12-week intervention
Type 2 Diabetes
Control Condition
1 sites across 1 states
Illinois1

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Eligibility criteria

Inclusion

At least 65 years old
Body mass index: 25-40 kg/m\^2
Female: Waist to hip ratio \>0.8
Male: Waist to hip ratio \>1.0
Free from structured exercise during the prior 6 months (mo) weight stable for the prior 6 months
Diagnosed by a physician with elevated glycosylated hemoglobin (HbA1c) \>6.5%
Normoglycemic with HbA1c levels not exceeding 5.6% and fasting blood glucose levels below or equal to 99 mg/dL (5.5mmol)

Exclusion

Uncontrolled diabetes (evidence of HbA1c \> 10%, prescription of insulin)
Diagnoses of diabetic neuropathy or failing diabetic neuropathy screening
Statins
Peripheral edema Consumption of ergogenic-levels of dietary supplements that may affect muscle mass (e.g., creatine, HMB), insulin-like substances, or anabolic/catabolic pro-hormones (e.g., DHEA) within 6 weeks prior to participation.
Untreated hypothyroidism, epilepsy, medications that affect vasoactivity, possibility of pregnancy, and any neurological, cardiovascular, or musculoskeletal disease that precludes exercise testing.
  • Define how exercise modifies protein efficiency in T2DFrom enrollment to end of 12-week intervention

    Define how exercise modifies protein efficiency by assessing whole-body net protein balance via amino acid oxidation rates in response to protein intake of 1.0 g protein/kg/d. We expect to observe elevated baseline (pre-training) rates of oxidative excretion in aging T2D compared with CON. Following 12 weeks of exercise, both groups will improve their whole-body net protein balance, (indicative of lower oxidation rates), but the largest effects will be observed in the T2D vs CON group