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Magnesium Sulfate Dosing for Postpartum Preeclampsia

This study is looking at how different lengths of treatment with magnesium sulfate affect women who have preeclampsia with severe features after giving birth. Preeclampsia with severe features means the condition has affected organs, causing high blood pressure or changes in lab tests. Participants will receive either 12 hours or 24 hours of magnesium sulfate after delivery. Researchers want to see how quickly certain lab values, like creatinine, ALT (alanine aminotransferase), and AST (aspartate aminotransferase), improve. These are markers of kidney and liver function. The study is recruiting women aged 18 to 45 who are delivering with preeclampsia with severe features. The study's status is currently unclear.

Study design
This is an interventional study with 100 planned participants. Participants will be randomly assigned to receive either 12 or 24 hours of magnesium sulfate after delivery.
What's involved
You would be enrolled while admitted to the Labor and Delivery Unit. Blood samples will be collected at delivery, 12 hours, 18 hours, and 24 hours after delivery. Your participation will last while you are in the hospital.
Compensation
Not stated in the trial record.
Follow-up
Your lab values will be monitored from the day of delivery through discharge, up to 4 days.

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NCT07478055

Biomarkers in Management of Post Partum Preeclampsia

Not Yet Recruiting
PHASE4Ages 18–45InterventionalTreatment
Alexander Harrison
~100 participants
Updated 2026-08-10 on ClinicalTrials.gov
What's tested:Magnesium Sulfate

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in creatinine
Measured over Day of delivery through discharge (up to 4 days)
+11 more outcomes measured

Conditions

Preeclampsia Severe
Preeclampsia Postpartum

Explore related trials

Preeclampsia

Where it's being run

1 sites across 1 states
Kentucky1

Study leadership

  • John O'Brien, MD · PRINCIPAL_INVESTIGATOR · University of Kentucky

Who to contact

Alexander M Harrison, MD
[email protected]
859-257-5158
Email the study team

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Eligibility criteria

Inclusion

The study population will consist of pregnant people ages 18 to 45 years old undergoing delivery in setting of preeclampsia with severe features as the experimental group and control (standard of care) groups
Diagnosis of PreEclampsia with severe featues must be made by standard clinical guidelines based on symptoms (persistent headache not responsive to medications, persistent right upper quadrant pain not responsive to medications), laboratory values (creatinine \>1.1mg/dL or twice the participants' baseline, AST or ALT \> twice the upper limit of normal or twice patient's blood line, platelets \<100,000), or blood pressure criteria (Systolic \>160 mmHg or Diastolic \>110mmHg persistent over 15 minutes such that short acting antihypertensives are required, or Systolic \>160mmHg or Diastolic\>110mmHg present 4 hours or more apart)

Exclusion

Multiple gestations (twins, triplets, etc)
Inability to consent in English

What this trial measures

  • Change in creatinineDay of delivery through discharge (up to 4 days)

    At time points (time of delivery, 12 hours post partum, 18 hours post partum, 24 hours post partum, then daily until discharge) serum will be analyzed for a change in biomarker levels.

  • Change in alanine aminotransferase (ALT)Day of delivery through discharge (up to 4 days)

    At time points (time of delivery, 12 hours post partum, 18 hours post partum, 24 hours post partum, then daily until discharge) serum will be analyzed for a change in biomarker levels.

  • Change in aspartate aminotransferase (AST)Day of delivery through discharge (up to 4 days)

    At time points (time of delivery, 12 hours post partum, 18 hours post partum, 24 hours post partum, then daily until discharge) serum will be analyzed for a change in biomarker levels.

  • Change in sFlt-1Day of delivery through discharge (up to 4 days)

    At time points (time of delivery, 12 hours post partum, 18 hours post partum, 24 hours post partum, then daily until discharge) serum will be analyzed for a change in biomarker levels.

  • Change in plateletsDay of delivery through discharge (up to 4 days)

    At time points (time of delivery, 12 hours post partum, 18 hours post partum, 24 hours post partum, then daily until discharge) serum will be analyzed for a change in biomarker levels.

  • Change in PlGFDay of delivery through discharge (up to 4 days)

    At time points (time of delivery, 12 hours post partum, 18 hours post partum, 24 hours post partum, then daily until discharge) serum will be analyzed for a change in biomarker levels.

  • Change in BNPDay of delivery through discharge (up to 4 days)

    At time points (time of delivery, 12 hours post partum, 18 hours post partum, 24 hours post partum, then daily until discharge) serum will be analyzed for a change in biomarker levels.

  • Change in VCAMDay of delivery through discharge (up to 4 days)

    At time points (time of delivery, 12 hours post partum, 18 hours post partum, 24 hours post partum, then daily until discharge) serum will be analyzed for a change in biomarker levels.

  • Change in ICAMDay of delivery through discharge (up to 4 days)

    At time points (time of delivery, 12 hours post partum, 18 hours post partum, 24 hours post partum, then daily until discharge) serum will be analyzed for a change in biomarker levels.

  • Change in tumor necrosis factor-alpha (TNF-alpha)Day of delivery through discharge (up to 4 days)

    At time points (time of delivery, 12 hours post partum, 18 hours post partum, 24 hours post partum, then daily until discharge) serum will be analyzed for a change in biomarker levels.

  • Change in Uric acidDay of delivery through discharge (up to 4 days)

    At time points (time of delivery, 12 hours post partum, 18 hours post partum, 24 hours post partum, then daily until discharge) serum will be analyzed for a change in biomarker levels.

  • Change in lactate dehydrogenase (LDH)Day of delivery through discharge (up to 4 days)

    At time points (time of delivery, 12 hours post partum, 18 hours post partum, 24 hours post partum, then daily until discharge) serum will be analyzed for a change in biomarker levels.