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Prehabilitation for Pancreatic Cancer Surgery

This study is looking at whether a structured program called "Multimodal Prehabilitation" can be successfully used by adults with pancreatic cancer who are having chemotherapy before planned surgery. Prehabilitation is a program that helps improve your physical fitness, nutrition, and how you manage symptoms before an operation. The researchers want to see if people can stick with this program during chemotherapy and if it might help with physical function, your experience, and recovery after surgery. You may be able to join if you are 18 or older, have pancreatic ductal adenocarcinoma (PDAC), are planning to have chemotherapy before surgery, and are healthy enough for physical activity. The study is currently unclear on its recruitment status.

Study design
This is a single-center pilot study with 20 participants. It is designed to evaluate how well the prehabilitation program can be put into practice.
What's involved
You would participate in a structured prehabilitation program during your neoadjuvant chemotherapy, which is expected to last about 3-6 months. This includes supervised exercise, nutritional counseling, and supportive care.
Compensation
Not stated in the trial record.
Follow-up
Assessments will be done at the start, after the prehabilitation period before surgery, and about one month after surgery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07478185

Prehab for Pancreatic Cancer Surgery

Recruiting
NAAges 18+InterventionalSupportive care
University of Massachusetts, Worcester
~20 participants
Updated 2026-04-03 on ClinicalTrials.gov
What's tested:Multimodal Prehabilitation

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Feasibility of prehabilitation program delivery
Measured over From enrollment through completion of neoadjuvant therapy (approximately 3-6 months)
+1 more outcome measured

Conditions

Pancreatic Cancer, Adult
Prehabilitation

Explore related trials

Pancreatic Ductal Adenocarcinoma

NCT07478185

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • UMass Memorial Medical Center

    Worester, Massachusettsstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • James M Lindberg, MD · PRINCIPAL_INVESTIGATOR · UMass Memorial Health

Who to contact

Kayla R Widdowson, MD
[email protected]
774-641-1257
Email the study team

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Eligibility criteria

Inclusion

Age ≥ 18 years
Diagnosis of pancreatic ductal adenocarcinoma (PDAC)
Planned neoadjuvant chemotherapy prior to planned surgical resection
Medically stable and cleared to participate in physical activity/exercise programming
Able to provide informed consent
Ability to read, write and understand English

Exclusion

Age \<18 years
Pregnant
Prisoner
Severe cognitive impairment that precludes informed consent or participation
Contraindications to physical activity, including unstable cardiac disease, severe pulmonary disease, or recent myocardial infarction

What this trial measures

  • Feasibility of prehabilitation program deliveryFrom enrollment through completion of neoadjuvant therapy (approximately 3-6 months)

    Feasibility will be assessed by the proportion of enrolled participants who initiate and complete the prehabilitation program during neoadjuvant chemotherapy prior to surgery.

  • Adherence to prehabilitation componentsFrom enrollment through preoperative assessment (approximately 3-6 months)

    Adherence will be measured by participant-reported completion of prescribed exercise sessions and reported completion of recommended preoperative immunonutrition.