This study is looking at how the brain's cerebellum (a part of the brain that helps with movement and balance) is connected to other brain areas in people experiencing their first episode of psychosis. Researchers want to see if these connections change when people are treated with either risperidone or aripiprazole, two common medications for psychosis. You might be able to join if you are 15 to 40 years old and have been diagnosed with a first-episode psychotic disorder, such as schizophrenia or bipolar disorder with psychosis, and are currently experiencing moderate positive symptoms. The study aims to enroll 120 participants. The study's success will be measured by changes in these brain connections over time.

Study design

This interventional study plans to enroll 120 participants. You will receive either risperidone or aripiprazole, which are standard treatments.

What's involved

You will have multimodal MRI scans (brain imaging) and clinical assessments at the start of the study. You will then receive treatment for 12 weeks, with clinical assessments for psychotic symptoms multiple times during this period.

Compensation

Not stated in the trial record.

Follow-up

Your brain connectivity will be measured between July 2025 and December 2029, indicating a long-term follow-up period after the 12-week treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.