Study on a Bundled Intervention to End Opioid Overdoses
This study is testing a new approach to help people with opioid use disorder (OUD) who have recently experienced an opioid overdose. It's called a "bundled intervention" and includes peer support, buprenorphine (a medication for OUD), telehealth services, and connections to community addiction programs. Researchers want to see if this bundled approach can reduce repeat opioid overdoses and improve treatment success compared to usual care at UAB Hospital. You might be able to join if you are 19 or older, have an OUD diagnosis, had an opioid overdose in the last year, were prescribed buprenorphine in the emergency department (ED), and are willing to continue buprenorphine after leaving the hospital. The study will look at how many people stay in the study, how well they take buprenorphine, and how many connect with addiction treatment programs over 1 and 3 months.
- Study design
- This interventional study plans to enroll 160 participants. It compares a bundled intervention to usual care.
- What's involved
- Participants in the experimental group will receive buprenorphine treatment, scheduled peer support throughout a 12-week intervention period, and telehealth-enabled services for 12 weeks.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for 3 months after hospital discharge to measure retention, buprenorphine adherence, and linkage to addiction treatment programs.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
A Bundled Intervention to End Opioid Overdoses
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Li Li, MD;PhD · PRINCIPAL_INVESTIGATOR · University of Alabama at Birmingham
Who to contact
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What this trial measures
- participant retention rate1 month and 3 months post hospital discharge
measure the total number of participants who complete 1- month and 3-month treatment in the study
- buprenorphine adherence rate1 month and 3 months post ED discharge
checking prescription rate and patients' self report of their taking medication
- linkage rate to addiction treatment programs1 month and 3 months post hospital discharge
patients' self report and reports from addiction treatment programs
- Frequency of Repeat Opioid OverdoseMonitored quarterly throughout the R33 study period beyond the 3-month intervention
Repeat opioid overdose events monitored through participant, family, and friend reports, and EMR documentation at UAB Hospital
- Healthcare Utilization (Hospital Revisit Rates)Monitored quarterly throughout the R33 study period beyond the 3-month intervention
Opioid overdose-related hospital revisits after the initial ED encounter, monitored via EMR documentation at UAB Hospital
- Adherence to Peer Support Specialist ContactThroughout the 12-week intervention period post hospital discharge
Rate of participant adherence to the scheduled peer support specialist contact protocol, including daily contact in Week 1, every other day contact in Week 2, and weekly contact in Weeks 3-12 post-ED discharge, as recorded in peer activity logs documenting dates, times, and length of each telehealth contact
- Opioid Overdose DeathMonitored quarterly throughout the R33 study period beyond the 3-month intervention
Opioid overdose deaths monitored through participant, family, and friend reports, and EMR documentation at UAB Hospital