Observational Study of fNIRS for Disorders of Consciousness
This study is looking at how a non-invasive brain imaging method called functional near-infrared spectroscopy (fNIRS) can measure brain activity. Researchers want to see if fNIRS can detect brain responses in healthy adults and in people with disorders of consciousness (DoC), such as coma or minimally conscious state, after a severe brain injury. Many standard tests for DoC rely on a person's ability to speak or move, which can be difficult after a brain injury. This study will use fNIRS monitoring while participants are exposed to sounds or asked to do mental tasks. The goal is to see if fNIRS can help doctors better understand a person's level of awareness when they can't respond behaviorally. You may be able to join if you are 18 or older and proficient in English. For those with DoC, a surrogate decision maker must be available, and you must have been admitted to the intensive care unit within 28 days.
- Study design
- This is an observational study with a planned enrollment of 55 participants. It is not specified if it is randomized or blinded.
- What's involved
- You would undergo fNIRS monitoring while receiving sensory stimuli and performing mental tasks. This session would last approximately 20-48 minutes.
- Compensation
- Not stated in the trial record.
- Follow-up
- The primary endpoint is measured during a single fNIRS recording session, so there is no specified follow-up period after this session.
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fNIRS for Disorders of Consciousness
At a glance
Conditions
NCT07485361
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
UCLA School of Nursing; Ronald Reagan Medical Center
Los Angeles, Californiano site contact published
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Who to contact
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Inclusion
Exclusion
What this trial measures
- Task-evoked cortical hemodynamic response measured with functional near-infrared spectroscopy (fNIRS)During a single fNIRS recording session (approximately 20-48 minutes, depending on participant group)
Cortical hemodynamic responses measured using fNIRS, quantified as changes in oxygenated hemoglobin (HbO) and deoxygenated hemoglobin (HbR) during somatosensory and cognitive task paradigms relative to rest periods.